Nature Communications (Apr 2019)
Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
- Sho Kubota,
- Kenji Tokunaga,
- Tomohiro Umezu,
- Takako Yokomizo-Nakano,
- Yuqi Sun,
- Motohiko Oshima,
- Kar Tong Tan,
- Henry Yang,
- Akinori Kanai,
- Eisaku Iwanaga,
- Norio Asou,
- Takahiro Maeda,
- Naomi Nakagata,
- Atsushi Iwama,
- Kazuma Ohyashiki,
- Motomi Osato,
- Goro Sashida
Affiliations
- Sho Kubota
- Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University
- Kenji Tokunaga
- Department of Hematology, Kumamoto University
- Tomohiro Umezu
- Department of Hematology, Tokyo Medical University
- Takako Yokomizo-Nakano
- Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University
- Yuqi Sun
- Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University
- Motohiko Oshima
- Department of Cellular and Molecular Medicine, Chiba University
- Kar Tong Tan
- Cancer Science Institute of Singapore, National University of Singapore
- Henry Yang
- Cancer Science Institute of Singapore, National University of Singapore
- Akinori Kanai
- Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University
- Eisaku Iwanaga
- Department of Hematology, Kumamoto University
- Norio Asou
- Department of Hematology, International Medical Center, Saitama Medical University
- Takahiro Maeda
- Department of General Medicine, Nagasaki University, Graduate School of Biomedical Science
- Naomi Nakagata
- Division of Reproductive Engineering, Center for Animal Resources and Development (CARD), Kumamoto University
- Atsushi Iwama
- Department of Cellular and Molecular Medicine, Chiba University
- Kazuma Ohyashiki
- Department of Hematology, Tokyo Medical University
- Motomi Osato
- Cancer Science Institute of Singapore, National University of Singapore
- Goro Sashida
- Laboratory of Transcriptional Regulation in Leukemogenesis, International Research Center for Medical Sciences (IRCMS), Kumamoto University
- DOI
- https://doi.org/10.1038/s41467-019-09710-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
Translocation of (6;8)(p21;q24), a recurrent abnormality of blastic plasmacytoid dendritic cell neoplasm, involves adjacent MYC and RUNX2 regions. Here, the authors show that the RUNX2 super-enhancer is hijacked to activate MYC in addition to RUNX2 expression, promoting the development of this cancer.
