Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Matthew Y. Tang; Marta Vranas; Andrea I. Krahn; Shayal Pundlik; Jean- François Trempe; Edward A. Fon

doi:10.1038/ncomms14697

Nature Communications (Mar 2017)

Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Matthew Y. Tang,
Marta Vranas,
Andrea I. Krahn,
Shayal Pundlik,
Jean- François Trempe,
Edward A. Fon

Affiliations

Matthew Y. Tang: Department of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill University
Marta Vranas: Department of Pharmacology and Therapeutics, Groupe de Recherche Axé sur la Structure des Protéines, McGill University
Andrea I. Krahn: Department of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill University
Shayal Pundlik: Department of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill University
Jean- François Trempe: Department of Pharmacology and Therapeutics, Groupe de Recherche Axé sur la Structure des Protéines, McGill University
Edward A. Fon: Department of Neurology and Neurosurgery, McGill Parkinson Program, Neurodegenerative Diseases Group, Montreal Neurological Institute, McGill University

DOI: https://doi.org/10.1038/ncomms14697
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Parkin and PINK1 are involved in damaged mitochondria clearance; however the sequence of events of Parkin activation is not clear. Here, the authors show that binding to phospho-ubiquitin on mitochondria enables Parkin phosphorylation, which allows Repressor Element of Parkin removal, E3 ligase activation and mitophagy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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