Synthesis and Antimicrobial Activity of N-Substituted-β-amino Acid Derivatives Containing 2-Hydroxyphenyl, Benzo[b]phenoxazine and Quinoxaline Moieties
Kristina Mickevičienė,
Rūta Baranauskaitė,
Kristina Kantminienė,
Maryna Stasevych,
Olena Komarovska-Porokhnyavets,
Volodymyr Novikov
Affiliations
Kristina Mickevičienė
Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania
Rūta Baranauskaitė
Department of Organic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania
Kristina Kantminienė
Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Kaunas 50254, Lithuania
Maryna Stasevych
Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine
Olena Komarovska-Porokhnyavets
Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine
Volodymyr Novikov
Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Politechnic National University, Lviv-13 79013, Ukraine
3-[(2-Hydroxyphenyl)amino]butanoic and 3-[(2-hydroxy-5-methyl(chloro)phenyl)amino]butanoic acids were converted to a series of derivatives containing hydrazide, pyrrole and chloroquinoxaline moieties. The corresponding benzo[b]phenoxazine derivatives were synthesized by the reaction of the obtained compounds with 2,3-dichloro-1,4-naphthoquinone. Five of the synthesized compounds exhibited good antimicrobial activity against Staphylococcus aureus and Mycobacterium luteum, whereas three compounds showed significant antifungal activity against Candida tenuis and Aspergillus niger.
