EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

C. Depner; H. zum Buttel; N. Böğürcü; A. M. Cuesta; M. R. Aburto; S. Seidel; F. Finkelmeier; F. Foss; J. Hofmann; K. Kaulich; S. Barbus; M. Segarra; G. Reifenberger; B. K. Garvalov; T. Acker; A. Acker-Palmer

doi:10.1038/ncomms12329

Nature Communications (Jul 2016)

EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance

C. Depner,
H. zum Buttel,
N. Böğürcü,
A. M. Cuesta,
M. R. Aburto,
S. Seidel,
F. Finkelmeier,
F. Foss,
J. Hofmann,
K. Kaulich,
S. Barbus,
M. Segarra,
G. Reifenberger,
B. K. Garvalov,
T. Acker,
A. Acker-Palmer

Affiliations

C. Depner: Institute of Neuropathology, University of Giessen
H. zum Buttel: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt
N. Böğürcü: Institute of Neuropathology, University of Giessen
A. M. Cuesta: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt
M. R. Aburto: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt
S. Seidel: Institute of Neuropathology, University of Giessen
F. Finkelmeier: Institute of Neuropathology, University of Giessen
F. Foss: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt
J. Hofmann: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt
K. Kaulich: Department of Neuropathology, Heinrich Heine University of Düsseldorf, Düsseldorf and German Cancer Consortium (DKTK)
S. Barbus: Division of Molecular Genetics, German Cancer Research Center (DKFZ)
M. Segarra: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt
G. Reifenberger: Department of Neuropathology, Heinrich Heine University of Düsseldorf, Düsseldorf and German Cancer Consortium (DKTK)
B. K. Garvalov: Institute of Neuropathology, University of Giessen
T. Acker: Institute of Neuropathology, University of Giessen
A. Acker-Palmer: Institute of Cell Biology and Neuroscience and Buchmann Institute for Molecular Life Sciences (BMLS), University of Frankfurt

DOI: https://doi.org/10.1038/ncomms12329
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Ephrins are transmembrane proteins involved in cell-cell communication, and implicated in cancer cell growth and progression. Here, the authors show that EphrinB2 expression is reduced in glioma cells both by genetic and epigenetic alterations and under hypoxia, through a HIF1α-mediated direct regulation of ZEB2, which enhances invasion and anti-angiogenic resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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