Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies

Sarah Gondek; Mateusz Ogledzinski; William Lin; Kamila Milejczyk; Braden Juengel; Lisa Potter; Piotr J. Bachul; Lindsay Basto; Laurencia Perea; Ling-Jia Wang; Martin Tibudan; Zuzanna Witkowska; Rolf Barth; John Fung; Piotr Witkowski

doi:166178

European Journal of Translational and Clinical Medicine (Jun 2023)

Persistence of long-term insulin independence after islet transplantation and two subsequent pregnancies

Sarah Gondek,
Mateusz Ogledzinski,
William Lin,
Kamila Milejczyk,
Braden Juengel,
Lisa Potter,
Piotr J. Bachul,
Lindsay Basto,
Laurencia Perea,
Ling-Jia Wang,
Martin Tibudan,
Zuzanna Witkowska,
Rolf Barth,
John Fung,
Piotr Witkowski

Affiliations

Sarah Gondek: ORCiD; The Transplantation Institute, University of Chicago, USA
Mateusz Ogledzinski: ORCiD; The Transplantation Institute, University of Chicago, USA
William Lin: ORCiD; The Transplantation Institute, University of Chicago, USA
Kamila Milejczyk: ORCiD; The Transplantation Institute, University of Chicago, USA
Braden Juengel: ORCiD; The Transplantation Institute, University of Chicago, USA
Lisa Potter: ORCiD; The Transplantation Institute, University of Chicago, USA
Piotr J. Bachul: ORCiD; The Transplantation Institute, University of Chicago, USA
Lindsay Basto: ORCiD; The Transplantation Institute, University of Chicago, USA
Laurencia Perea: ORCiD; The Transplantation Institute, University of Chicago, USA
Ling-Jia Wang: ORCiD; The Transplantation Institute, University of Chicago, USA
Martin Tibudan: ORCiD; The Transplantation Institute, University of Chicago, USA
Zuzanna Witkowska: ORCiD; The Transplantation Institute, University of Chicago, USA
Rolf Barth: ORCiD; The Transplantation Institute, University of Chicago, USA
John Fung: ORCiD; The Transplantation Institute, University of Chicago, USA
Piotr Witkowski: ORCiD; The Transplantation Institute, University of Chicago, USA

DOI
Journal volume & issue: Vol. 6, no. 1
pp. 9 – 13

Abstract

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Pregnancy increases metabolic demand for insulin and may lead to the exhaustion of intraportally transplanted islets and post-gestational hyperglycemia. To prevent these complications, we implemented preemptive insulin supplementation during two subsequent pregnancies in an insulin-independent islet transplant recipient. This strategy resulted in optimal blood glucose control during the pregnancies, the preservation of the optimal islet graft function and the postpartum maintenance of long-term insulin independence.

Published in European Journal of Translational and Clinical Medicine

ISSN: 2657-3148 (Print); 2657-3156 (Online)
Publisher: Medical University of Gdańsk
Country of publisher: Poland
LCC subjects: Medicine
Website: https://ejtcm.gumed.edu.pl/about

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Abstract

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