Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth

Jun Li; Jie Ma; Qiyu Zhang; Huizi Gong; Dunqin Gao; Yujie Wang; Biyou Li; Xiao Li; Heyi Zheng; Zhihong Wu; Yunping Zhu; Ling Leng

doi:10.1038/s41467-022-31659-9

Nature Communications (Jul 2022)

Spatially resolved proteomic map shows that extracellular matrix regulates epidermal growth

Jun Li,
Jie Ma,
Qiyu Zhang,
Huizi Gong,
Dunqin Gao,
Yujie Wang,
Biyou Li,
Xiao Li,
Heyi Zheng,
Zhihong Wu,
Yunping Zhu,
Ling Leng

Affiliations

Jun Li: Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Jie Ma: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
Qiyu Zhang: Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Huizi Gong: Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Dunqin Gao: Stem Cell and Regenerative Medicine Lab, State Key Laboratory of Complex Severe and Rare Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yujie Wang: Stem Cell and Regenerative Medicine Lab, State Key Laboratory of Complex Severe and Rare Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Biyou Li: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
Xiao Li: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
Heyi Zheng: Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Zhihong Wu: Stem Cell and Regenerative Medicine Lab, State Key Laboratory of Complex Severe and Rare Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Yunping Zhu: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics
Ling Leng: Stem Cell and Regenerative Medicine Lab, State Key Laboratory of Complex Severe and Rare Diseases, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

DOI: https://doi.org/10.1038/s41467-022-31659-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

Ling Leng et al. construct a hierarchical skin proteome map and identify an extracellular matrix glycoprotein TGFBI, which is located in basement membrane and could enhance the growth and function of epidermal stem cells and promote wound healing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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