Frontiers in Oncology (May 2022)

Primary Leiomyosarcoma of the Glans

  • Raimundo Nonato Gois da Costa Junior,
  • Antonio Augusto Lima Teixeira Júnior,
  • Antonio Augusto Lima Teixeira Júnior,
  • Thalita Moura Silva Rocha,
  • Thaís Bastos Moraes Sobrinho,
  • Liseana de Oliveira Barbosa,
  • Rafael Campos Silva,
  • Rita da Graça Carvalhal Frazão Corrêa,
  • Antonio Machado Alencar Junior,
  • Francisco Sergio Moura Silva Nascimento,
  • Syomara Pereira da Costa Melo,
  • José Ribamar Rodrigues Calixto,
  • Gyl Eanes Barros Silva,
  • Gyl Eanes Barros Silva

DOI
https://doi.org/10.3389/fonc.2022.851003
Journal volume & issue
Vol. 12

Abstract

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Penile leiomyosarcoma isz an extremely uncommon entity that rarely occurs in the glans. Due to the limited number of cases described in literature, guidelines regarding non-surgical treatment, prognosis, and management remain equivocal. Among the mesenchymal tumors of the penis, leiomyosarcoma has the highest propensity for recurrence. It originates in the smooth muscle cells from two distinct locations: superficial and deep. The deep subtype is the most aggressive and has the highest potential for metastasis. Surgical treatment should be implemented early and must be locally aggressive. Herein, we present a rare case of a 54-year-old patient with deep localized leiomyosarcoma of the glans, albeit with superficial characteristics. A review of the main histopathological, clinical, immunohistochemical, and therapeutic aspects of this unusual entity is presented.

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