Relationship between atherogenic index of plasma and valvular calcification in elderly patients with degenerative valvular heart disease

Abstract

[Objective] To investigate the relationship between arteriosclerosis index of plasma and valvular calcification in elderly patients with degenerative valvular heart disease. [Methods] A total of 148 elderly patients with degenerative valvular heart disease treated in Weifang People’s Hospital from September 2022 to February 2024 were retrospectively collected. According to whether the patients had valvular calcification, they were divided into a calcification group (92 cases) and a non-calcification group (56 cases). Multivariate logistic regression was used to analyze the influencing factors of valvular calcification in elderly patients with degenerative valvular heart disease, and ROC curve was used to analyze the predictive value of plasma arteriosclerosis index, triglycerides, and high-density lipoprotein cholesterol for valvular calcification in elderly patients with degenerative valvular heart disease. [Results] Fasting blood glucose, high-density lipoprotein cholesterol and plasma-induced arteriosclerosis index in the calcification group were higher than those in the non-calcification group, triglyceride was lower than that in the non-calcification group, and the differences had statistical significance (P0.05). Multivariate logistic regression analysis showed that fasting blood glucose, high-density lipoprotein cholesterol and plasma arteriosclerosis index were independent risk factors for valvular calcification in elderly patients with degenerative valvular heart disease (P<0.05), and triglycerides were protective factors (P < 0.05). ROC curve analysis showed that the plasma atherogenic index predicted the highest area under the curve for the occurrence of valvular calcification in elderly patients with degenerative valvular heart disease, 0.853 (95% CI: 0.790 to 0.915, P < 0.05), the optimal threshold was 0.175, the sensitivity was 0.804, the specificity was 0.857, and the Youden index was 0.661. [Conclusion] Atherogenic index of plasma is an independent predictor of valvular calcification in elderly patients with degenerative valvular heart disease, which has a high diagnostic value and can provide a basis for early clinical identification of high-risk groups and provide new ideas for the prevention and intervention of valvular calcification progression.

Keywords

• atherogenic index of plasma
• degenerative valvular heart disease
• valve calcification