Nature Communications (Jan 2021)
The p63 C-terminus is essential for murine oocyte integrity
- Anna Maria Lena,
- Valerio Rossi,
- Susanne Osterburg,
- Artem Smirnov,
- Christian Osterburg,
- Marcel Tuppi,
- Angela Cappello,
- Ivano Amelio,
- Volker Dötsch,
- Massimo De Felici,
- Francesca Gioia Klinger,
- Margherita Annicchiarico-Petruzzelli,
- Herbert Valensise,
- Gerry Melino,
- Eleonora Candi
Affiliations
- Anna Maria Lena
- Department of Experimental Medicine, University of Rome “Tor Vergata”
- Valerio Rossi
- Department of Biomedicine and Prevention, University of Rome Tor Vergata
- Susanne Osterburg
- Institute of Biophysical Chemistry, Center for Biomolecular Magnetic Resonance and Cluster of Excellence Macromolecular Complexes (CEF), Goethe University
- Artem Smirnov
- Department of Experimental Medicine, University of Rome “Tor Vergata”
- Christian Osterburg
- Institute of Biophysical Chemistry, Center for Biomolecular Magnetic Resonance and Cluster of Excellence Macromolecular Complexes (CEF), Goethe University
- Marcel Tuppi
- Institute of Biophysical Chemistry, Center for Biomolecular Magnetic Resonance and Cluster of Excellence Macromolecular Complexes (CEF), Goethe University
- Angela Cappello
- Department of Experimental Medicine, University of Rome “Tor Vergata”
- Ivano Amelio
- Department of Experimental Medicine, University of Rome “Tor Vergata”
- Volker Dötsch
- Institute of Biophysical Chemistry, Center for Biomolecular Magnetic Resonance and Cluster of Excellence Macromolecular Complexes (CEF), Goethe University
- Massimo De Felici
- Department of Biomedicine and Prevention, University of Rome Tor Vergata
- Francesca Gioia Klinger
- Department of Biomedicine and Prevention, University of Rome Tor Vergata
- Margherita Annicchiarico-Petruzzelli
- IDI-IRCCS, Via dei Monti di Creta
- Herbert Valensise
- Department of Surgery, University of Rome “Tor Vergata”
- Gerry Melino
- Department of Experimental Medicine, University of Rome “Tor Vergata”
- Eleonora Candi
- Department of Experimental Medicine, University of Rome “Tor Vergata”
- DOI
- https://doi.org/10.1038/s41467-020-20669-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The transcription factor p63 mediates different cellular responses affecting epithelial and oocyte biology. Here, the authors generate a mouse model (HET Δ13p63 mice) expressing the p63β isoform and show this affects ovary development, phenocopying a human syndrome, primary ovary insufficiency.
