Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication

Kan Xing Wu; Patchara Phuektes; Pankaj Kumar; Germaine Yen Lin Goh; Dimitri Moreau; Vincent Tak Kwong Chow; Frederic Bard; Justin Jang Hann Chu

doi:10.1038/ncomms13150

Nature Communications (Oct 2016)

Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication

Kan Xing Wu,
Patchara Phuektes,
Pankaj Kumar,
Germaine Yen Lin Goh,
Dimitri Moreau,
Vincent Tak Kwong Chow,
Frederic Bard,
Justin Jang Hann Chu

Affiliations

Kan Xing Wu: Department of Microbiology and Immunology, National University of Singapore
Patchara Phuektes: Department of Microbiology and Immunology, National University of Singapore
Pankaj Kumar: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)
Germaine Yen Lin Goh: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)
Dimitri Moreau: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)
Vincent Tak Kwong Chow: Department of Microbiology and Immunology, National University of Singapore
Frederic Bard: Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)
Justin Jang Hann Chu: Department of Microbiology and Immunology, National University of Singapore

DOI: https://doi.org/10.1038/ncomms13150
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Enterovirus 71 (EV71) infection causes a spectrum of symptoms including neurological disease. To improve our understanding of EV71-host interactions, Wu et al. here perform a genome-wide RNAi screen, which implicates cell cycle regulation and ER-associated degradation as important factors in EV71 replication.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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