Nature Communications (Jan 2020)
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
- Sonia Shah,
- Albert Henry,
- Carolina Roselli,
- Honghuang Lin,
- Garðar Sveinbjörnsson,
- Ghazaleh Fatemifar,
- Åsa K. Hedman,
- Jemma B. Wilk,
- Michael P. Morley,
- Mark D. Chaffin,
- Anna Helgadottir,
- Niek Verweij,
- Abbas Dehghan,
- Peter Almgren,
- Charlotte Andersson,
- Krishna G. Aragam,
- Johan Ärnlöv,
- Joshua D. Backman,
- Mary L. Biggs,
- Heather L. Bloom,
- Jeffrey Brandimarto,
- Michael R. Brown,
- Leonard Buckbinder,
- David J. Carey,
- Daniel I. Chasman,
- Xing Chen,
- Xu Chen,
- Jonathan Chung,
- William Chutkow,
- James P. Cook,
- Graciela E. Delgado,
- Spiros Denaxas,
- Alexander S. Doney,
- Marcus Dörr,
- Samuel C. Dudley,
- Michael E. Dunn,
- Gunnar Engström,
- Tõnu Esko,
- Stephan B. Felix,
- Chris Finan,
- Ian Ford,
- Mohsen Ghanbari,
- Sahar Ghasemi,
- Vilmantas Giedraitis,
- Franco Giulianini,
- John S. Gottdiener,
- Stefan Gross,
- Daníel F. Guðbjartsson,
- Rebecca Gutmann,
- Christopher M. Haggerty,
- Pim van der Harst,
- Craig L. Hyde,
- Erik Ingelsson,
- J. Wouter Jukema,
- Maryam Kavousi,
- Kay-Tee Khaw,
- Marcus E. Kleber,
- Lars Køber,
- Andrea Koekemoer,
- Claudia Langenberg,
- Lars Lind,
- Cecilia M. Lindgren,
- Barry London,
- Luca A. Lotta,
- Ruth C. Lovering,
- Jian’an Luan,
- Patrik Magnusson,
- Anubha Mahajan,
- Kenneth B. Margulies,
- Winfried März,
- Olle Melander,
- Ify R. Mordi,
- Thomas Morgan,
- Andrew D. Morris,
- Andrew P. Morris,
- Alanna C. Morrison,
- Michael W. Nagle,
- Christopher P. Nelson,
- Alexander Niessner,
- Teemu Niiranen,
- Michelle L. O’Donoghue,
- Anjali T. Owens,
- Colin N. A. Palmer,
- Helen M. Parry,
- Markus Perola,
- Eliana Portilla-Fernandez,
- Bruce M. Psaty,
- Regeneron Genetics Center,
- Kenneth M. Rice,
- Paul M. Ridker,
- Simon P. R. Romaine,
- Jerome I. Rotter,
- Perttu Salo,
- Veikko Salomaa,
- Jessica van Setten,
- Alaa A. Shalaby,
- Diane T. Smelser,
- Nicholas L. Smith,
- Steen Stender,
- David J. Stott,
- Per Svensson,
- Mari-Liis Tammesoo,
- Kent D. Taylor,
- Maris Teder-Laving,
- Alexander Teumer,
- Guðmundur Thorgeirsson,
- Unnur Thorsteinsdottir,
- Christian Torp-Pedersen,
- Stella Trompet,
- Benoit Tyl,
- Andre G. Uitterlinden,
- Abirami Veluchamy,
- Uwe Völker,
- Adriaan A. Voors,
- Xiaosong Wang,
- Nicholas J. Wareham,
- Dawn Waterworth,
- Peter E. Weeke,
- Raul Weiss,
- Kerri L. Wiggins,
- Heming Xing,
- Laura M. Yerges-Armstrong,
- Bing Yu,
- Faiez Zannad,
- Jing Hua Zhao,
- Harry Hemingway,
- Nilesh J. Samani,
- John J. V. McMurray,
- Jian Yang,
- Peter M. Visscher,
- Christopher Newton-Cheh,
- Anders Malarstig,
- Hilma Holm,
- Steven A. Lubitz,
- Naveed Sattar,
- Michael V. Holmes,
- Thomas P. Cappola,
- Folkert W. Asselbergs,
- Aroon D. Hingorani,
- Karoline Kuchenbaecker,
- Patrick T. Ellinor,
- Chim C. Lang,
- Kari Stefansson,
- J. Gustav Smith,
- Ramachandran S. Vasan,
- Daniel I. Swerdlow,
- R. Thomas Lumbers
Affiliations
- Sonia Shah
- Institute for Molecular Bioscience, The University of Queensland
- Albert Henry
- Institute of Cardiovascular Science, University College London
- Carolina Roselli
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Honghuang Lin
- Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine
- Garðar Sveinbjörnsson
- deCODE genetics/Amgen Inc.
- Ghazaleh Fatemifar
- British Heart Foundation Research Accelerator, University College London
- Åsa K. Hedman
- Cardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute
- Jemma B. Wilk
- Pfizer Worldwide Research & Development
- Michael P. Morley
- Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
- Mark D. Chaffin
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Anna Helgadottir
- deCODE genetics/Amgen Inc.
- Niek Verweij
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Abbas Dehghan
- Department of Epidemiology and Biostatistics, Imperial College London, St Mary’s Campus
- Peter Almgren
- Department of Clinical Sciences, Lund University
- Charlotte Andersson
- National Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart Study
- Krishna G. Aragam
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Johan Ärnlöv
- Department of Neurobiology, Care Sciences and Society/ Section of Family Medicine and Primary Care, Karolinska Institutet
- Joshua D. Backman
- Regeneron Genetics Center
- Mary L. Biggs
- Department of Biostatistics, University of Washington
- Heather L. Bloom
- Division of Cardiology, Department of Medicine, Emory University Medical Center
- Jeffrey Brandimarto
- Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
- Michael R. Brown
- Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health
- Leonard Buckbinder
- Pfizer Worldwide Research & Development
- David J. Carey
- Department of Molecular and Functional Genomics, Geisinger
- Daniel I. Chasman
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Xing Chen
- Pfizer Worldwide Research & Development
- Xu Chen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Jonathan Chung
- Regeneron Genetics Center
- William Chutkow
- Novartis Institutes for Biomedical Research
- James P. Cook
- Department of Biostatistics, University of Liverpool
- Graciela E. Delgado
- Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg
- Spiros Denaxas
- British Heart Foundation Research Accelerator, University College London
- Alexander S. Doney
- Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School
- Marcus Dörr
- Department of Internal Medicine B, University Medicine Greifswald
- Samuel C. Dudley
- Cardiovascular Division, Department of Medicine, University of Minnesota
- Michael E. Dunn
- Regeneron Pharmaceuticals, Cardiovascular Research
- Gunnar Engström
- Department of Clinical Sciences, Lund University
- Tõnu Esko
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Stephan B. Felix
- Department of Internal Medicine B, University Medicine Greifswald
- Chris Finan
- Institute of Cardiovascular Science, University College London
- Ian Ford
- Robertson Center for Biostatistics, University of Glasgow
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus University Medical Center
- Sahar Ghasemi
- DZHK (German Center for Cardiovascular Research), partner site Greifswald
- Vilmantas Giedraitis
- Department of Public Health and Caring Sciences, Geriatrics, Uppsala University
- Franco Giulianini
- Division of Preventive Medicine, Brigham and Women’s Hospital
- John S. Gottdiener
- Department of Medicine, Division of Cardiology, University of Maryland School of Medicine
- Stefan Gross
- Department of Internal Medicine B, University Medicine Greifswald
- Daníel F. Guðbjartsson
- deCODE genetics/Amgen Inc.
- Rebecca Gutmann
- Division of Cardiovascular Medicine, University of Iowa Carver College of Medicine
- Christopher M. Haggerty
- Department of Molecular and Functional Genomics, Geisinger
- Pim van der Harst
- Department of Cardiology, University Medical Center Groningen, University of Groningen
- Craig L. Hyde
- Pfizer Worldwide Research & Development
- Erik Ingelsson
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Maryam Kavousi
- Department of Epidemiology, Erasmus University Medical Center
- Kay-Tee Khaw
- Department of Public Health and Primary Care, University of Cambridge
- Marcus E. Kleber
- Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg
- Lars Køber
- Department of Cardiology, Copenhagen University Hospital Rigshospitalet
- Andrea Koekemoer
- Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital
- Claudia Langenberg
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Lars Lind
- Department of Medical Sciences, Uppsala University
- Cecilia M. Lindgren
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Barry London
- Division of Cardiovascular Medicine and Abboud Cardiovascular Research Center, University of Iowa
- Luca A. Lotta
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Ruth C. Lovering
- Institute of Cardiovascular Science, University College London
- Jian’an Luan
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Patrik Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Anubha Mahajan
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Kenneth B. Margulies
- Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
- Winfried März
- Department of Biostatistics, University of Liverpool
- Olle Melander
- Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital
- Ify R. Mordi
- Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School
- Thomas Morgan
- Novartis Institutes for Biomedical Research
- Andrew D. Morris
- Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Andrew P. Morris
- Department of Biostatistics, University of Liverpool
- Alanna C. Morrison
- Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health
- Michael W. Nagle
- Pfizer Worldwide Research & Development
- Christopher P. Nelson
- Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital
- Alexander Niessner
- Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna
- Teemu Niiranen
- National Institute for Health and Welfare
- Michelle L. O’Donoghue
- TIMI Study Group, Cardiovascular Division, Brigham and Women’s Hospital
- Anjali T. Owens
- Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
- Colin N. A. Palmer
- Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School
- Helen M. Parry
- Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School
- Markus Perola
- National Institute for Health and Welfare
- Eliana Portilla-Fernandez
- Department of Epidemiology, Erasmus University Medical Center
- Bruce M. Psaty
- Department of Medicine, Epidemiology, and Health Services, University of Washington
- Regeneron Genetics Center
- Kenneth M. Rice
- Department of Biostatistics, University of Washington
- Paul M. Ridker
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Simon P. R. Romaine
- Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- Perttu Salo
- National Institute for Health and Welfare
- Veikko Salomaa
- National Institute for Health and Welfare
- Jessica van Setten
- Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, University of Utrecht
- Alaa A. Shalaby
- Division of Cardiology, Department of Medicine, University of Pittsburgh Medical Center and VA Pittsburgh HCS
- Diane T. Smelser
- Department of Molecular and Functional Genomics, Geisinger
- Nicholas L. Smith
- Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington
- Steen Stender
- Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev and Gentofte
- David J. Stott
- Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow
- Per Svensson
- Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet
- Mari-Liis Tammesoo
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Kent D. Taylor
- Institute for Translational Genomics and Population Sciences, LABiomed and Departments of Pediatrics at Harbor-UCLA Medical Center
- Maris Teder-Laving
- Estonian Genome Center, Institute of Genomics, University of Tartu
- Alexander Teumer
- DZHK (German Center for Cardiovascular Research), partner site Greifswald
- Guðmundur Thorgeirsson
- deCODE genetics/Amgen Inc.
- Unnur Thorsteinsdottir
- deCODE genetics/Amgen Inc.
- Christian Torp-Pedersen
- Department of Epidemiology and Biostatistics, Aalborg University Hospital
- Stella Trompet
- Department of Cardiology, Leiden University Medical Center
- Benoit Tyl
- Translational and Clinical Research, Servier Cardiovascular Center for Therapeutic Innovation, 50 rue Carnot
- Andre G. Uitterlinden
- Department of Epidemiology, Erasmus University Medical Center
- Abirami Veluchamy
- Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School
- Uwe Völker
- DZHK (German Center for Cardiovascular Research), partner site Greifswald
- Adriaan A. Voors
- Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine
- Xiaosong Wang
- Novartis Institutes for Biomedical Research
- Nicholas J. Wareham
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Dawn Waterworth
- Human Genetics, GlaxoSmithKline
- Peter E. Weeke
- Department of Cardiology, Copenhagen University Hospital Rigshospitalet
- Raul Weiss
- Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University Medical Center
- Kerri L. Wiggins
- Department of Medicine, University of Washington
- Heming Xing
- Novartis Institutes for Biomedical Research
- Laura M. Yerges-Armstrong
- Human Genetics, GlaxoSmithKline
- Bing Yu
- Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health
- Faiez Zannad
- Université de Lorraine, CHU de Nancy, Inserm and INI-CRCT (F-CRIN), Institut Lorrain du Coeur et des Vaisseaux
- Jing Hua Zhao
- MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine
- Harry Hemingway
- British Heart Foundation Research Accelerator, University College London
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital
- John J. V. McMurray
- BHF Cardiovascular Research Centre, University of Glasgow
- Jian Yang
- Institute for Molecular Bioscience, The University of Queensland
- Peter M. Visscher
- Institute for Molecular Bioscience, The University of Queensland
- Christopher Newton-Cheh
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Anders Malarstig
- Cardiovascular Medicine unit, Department of Medicine Solna, Karolinska Institute
- Hilma Holm
- deCODE genetics/Amgen Inc.
- Steven A. Lubitz
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Naveed Sattar
- BHF Cardiovascular Research Centre, University of Glasgow
- Michael V. Holmes
- Medical Research Council Population Health Research Unit at the University of Oxford
- Thomas P. Cappola
- Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
- Folkert W. Asselbergs
- Institute of Cardiovascular Science, University College London
- Aroon D. Hingorani
- Institute of Cardiovascular Science, University College London
- Karoline Kuchenbaecker
- Division of Psychiatry, University College of London
- Patrick T. Ellinor
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Chim C. Lang
- Division of Molecular & Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School
- Kari Stefansson
- deCODE genetics/Amgen Inc.
- J. Gustav Smith
- Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard
- Ramachandran S. Vasan
- National Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart Study
- Daniel I. Swerdlow
- Institute of Cardiovascular Science, University College London
- R. Thomas Lumbers
- British Heart Foundation Research Accelerator, University College London
- DOI
- https://doi.org/10.1038/s41467-019-13690-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.
