Analysis of the efficacy of different amounts of parathyroid grafts in the treatment of secondary hyperparathyroidism

Abstract

Abstract Purpose This study compares the efficacy of two different ranges of parathyroid transplantation weights with the aim of determining a preferable range for transplantation weight. Methods From May 2018 to June 2023, 79 patients underwent total parathyroidectomy with autotransplantation. Demographic data, symptoms, and pre- or postoperative biochemical indicators were compared between two different ranges of parathyroid transplantation weights. Results All 79 surgeries were successful, with a total of 316 parathyroid glands reported among the patients. The patients were diagnosed with parathyroid hyperplasia. Postoperatively, itching, bone pain, and muscle weakness disappeared, while serum parathyroid hormone and phosphate levels significantly decreased. With an average follow-up of 12 months, no transplant-dependent recurrence was observed. Conclusion Parathyroid transplantation with a weight of 30–50 mg is a feasible, safe, and effective surgical approach.

Keywords

• Secondary hyperparathyroidism
• Chronic kidney disease
• Total parathyroidectomy
• Parathyroid hormone
• Autotransplantation