Analysis of the Microbial Landscape of Infection Site and the Effectiveness of Antibiotic and Immunotherapy in Patients with Diabetic Foot

Abstract

The article analyses the results of the study of 169 strains of microorganisms obtained from wound discharge from 132 patients with diabetes mellitus. Staphylococcus spp. bacteria held a leading place among Gram-positive pathogens. Gram-negative pathogens — Escherichia coli, Pseudomonas aeruginosa, etc. — were found less frequently. All isolated cultures were sensitive to levofloxacin and moxifloxacin, and only Acinetobacter spp. (n=2) remained intact (in vitro) after the use of levofloxacin. The intra-arterial route of administration of levofloxacin (500 mg/day) in combination with polyoxidonium (12 mg/day) through a port was used in 16 patients with diabetic foot. In all clinical cases, positive dynamics was noted: subsiding of the inflammatory process, cleansing of the wound from a purulent-necrotic substrate, and early epithelialization of the wound was observed in patients with diabetic foot.

Keywords

• diabetes mellitus
• diabetic foot
• wound infection
• polyoxidonium
• pentaglobin
• levofloxacin