Медицинская иммунология (Jul 2014)

HLA DRB1* ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN

  • L. A. Gordeeva,
  • A. V. Shabaldin,
  • A. N. Glushkov,
  • O. A. Glushkova,
  • O. S. Makarchenko,
  • T. A. Simonova,
  • I. V. Vetrova,
  • E. A. Sherina,
  • N. K. Zhilinskaya,
  • V. I. Minina

DOI
https://doi.org/10.15789/1563-0625-2007-6-643-648
Journal volume & issue
Vol. 9, no. 6
pp. 643 – 648

Abstract

Read online

Abstract. HLA DRB1* gene associations with idiopathic fetal losses and infertility were studied in women. It was shown that idiopathic fetal losses are associated with HLA DRB1*04 specificity, whereas infertility correlated with HLA DRB1*04/07 genotype. The associations revealed may indicate to a special role of autoimmune events in women during pregnancy. The authors suggest a hypothesis on existence of several immune modes of reproductive losses. HLA genotyping may be applied as a basic technique for their determination.

Keywords