Journal of Diabetology (Jan 2015)
Risk of coronary heart disease in type 2 diabetes: a follow-up study of Bangladeshi population
Abstract
The aim of this study was to determine the potential risk factors of CHD in Type 2 diabetic patients. We studied 2887 diabetic patients from the Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) registry record books for the period from 1984 to 1997. We included socio- demographic information (age, sex, residence and education), anthropometry (height, weight) and blood pressure. Body mass index (BMI) and mean arterial blood pressure (MABP) were calculated. Also, the time from the diagnosis of type 2 diabetes mellitus (T2DM) to the occurrence of CHD was recorded. We used the logistic regression model and examined the potential risk factors. We have studied 2887 Type 2 diabetic patients. Among them male and female participants were 67.3% and 32.7% respectively. Their mean (SD) age was 52.69 (12.41) years, BMI was 22.92 (3.80) and MABP was 97.26 (11.53). The mean (SD) of 2-hBG was 12.39 (3.37) mmol/l. The subject with advanced age (1.7 vs. 5.7%; χ2=11.12, p= 0.001), increasing BMI (p=0.000) and MABP (p=0.000), and urban (p=0.000) participant had significantly higher prevalence of CHD than compared with the lower (age ≤ 40, BMI ≤ 21.46, MABP ≤ 93.33 ) groups and rural counterpart. The logistic regression analysis also showed that urban subjects, literate population, and increased age, BMI and MABP were the important risk factors of CHD with diabetes. We conclude that older age, obesity and high blood pressure were significant risk factors of CHD with diabetes. Compared with rural subjects, the urban subjects showed significantly greater risk for CHD. We couldn′t find any correlation with the increasing 2-hBG as a significant risk factor of CHD.
