Value of neutrophil-to-lymphocyte ratio in neuronal intranuclear inclusion disease
Nan Du,
Lei Bao,
Jing Zhang,
Xiaowen Li,
Jin Tian,
Man Xia,
Wei Chen,
Pinyi Zhu,
XiuJuan Sun,
Min Wang,
Yihan Wu,
Lin He,
Yang Gao,
Wen sun,
Zunsheng Zhang,
Hao Chen
Affiliations
Nan Du
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China
Lei Bao
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China
Jing Zhang
Department of Neurology, Xuanwu Hospital, Capital Medical University, Xicheng District, Beijing, 100053, China
Xiaowen Li
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China
Jin Tian
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China
Man Xia
Department of Neurological Intensive Care, Yantai Yuhuangding Hospital, Yantai, 264000, China
Wei Chen
Department of Neurology,Tengzhou Central People's Hospital, Tengzhou, Shandong, 277500, China
Pinyi Zhu
Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210029, China
XiuJuan Sun
Department of Neurology, Liaocheng People's Hospital and Liaocheng Hospital Affiliated to Shandong First Medical University, Liaocheng, Shandong, 252000, China
Min Wang
Department of Neurology, The Second Hospital of Shandong University, Jinan, Shandong, 250033, China
Yihan Wu
Department of Family Medicine, Inner Mongolia People's Hospital, Hohhot, 010057, China
Lin He
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China
Yang Gao
The Yancheng Clinical College of Xuzhou Medical University, No 166 Yulong Road, Yancheng, Jiangsu, 224000, China; Department of Neurology, Yancheng City No.1 People's Hospital, No 166 Yulong Road, Yancheng, Jiangsu, 224000, China
Wen sun
Stroke Center and Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China
Zunsheng Zhang
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China
Hao Chen
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Department of Neurology, Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China; Corresponding author. Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, China.
Background and objectives: The neutrophil-to-lymphocyte ratio (NLR) is a widely recognized marker of inflammation in peripheral blood. However, its specific role in neuronal intranuclear inclusion disease (NIID) has not been reported. This study aims to investigate the relationship between NIID and NLR. Methods: A multicenter database was collected, including 157 NIID patients from seven hospitals (The Affiliated Hospital of Xuzhou Medical University, Yantai Yuhuangding Hospital, Tengzhou Central People's Hospital,The Affiliated Brain Hospital of Nanjing Medical University, Liaocheng People's Hospital,The Second Hospital of Shandong University, Inner Mongolia People's Hospital, Xuanwu Hospital Capital Medical University,The First Affiliated Hospital of USTC), along with 157 age- and gender-matched healthy control subjects. White blood cell counts (including neutrophils, lymphocytes, monocytes, eosinophils, and basophils) were obtained, and the NLR was calculated. Additionally, cognitive impairment was assessed using clinical evaluation scores. Results: NIID patients exhibited significantly higher NLR values compared to the healthy control group (p 0.05). Conclusion: There is a significant association between NLR and NIID, suggesting a potential role of peripheral blood inflammation in the pathogenesis of NIID.
