Investigation of Chemical Compounds from Phomopsis Extract as Anti-Breast Cancer Using LC-MS/MS Analysis, Molecular Docking, and Molecular Dynamic Simulations

Husnawati; Kusmardi Kusmardi; Rini Kurniasih; AE Zainal Hasan; Dimas Andrianto; Heddy  Julistiono; Bambang Pontjo Priosoeryanto; I Made Artika; Mohd Nazil  Salleh

doi:10.14716/ijtech.v14i7.6696

International Journal of Technology (Dec 2023)

Investigation of Chemical Compounds from Phomopsis Extract as Anti-Breast Cancer Using LC-MS/MS Analysis, Molecular Docking, and Molecular Dynamic Simulations

Husnawati,
Kusmardi Kusmardi,
Rini Kurniasih,
AE Zainal Hasan,
Dimas Andrianto,
Heddy Julistiono,
Bambang Pontjo Priosoeryanto,
I Made Artika,
Mohd Nazil Salleh

Affiliations

Husnawati: 1. Doctoral Program of Biomedical Science, Faculty of Medicine, Universitas Indonesia, 10430, Jakarta, Indonesia, 2. Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB Unive
Kusmardi Kusmardi: 1. Department Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, 10430, Jakarta, Indonesia. 2. Drug Development Research Center, Indonesia Medical Education and Research Institute (IMER
Rini Kurniasih: Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, 16680, Bogor, Indonesia
AE Zainal Hasan: Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, 16680, Bogor, Indonesia
Dimas Andrianto: Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, 16680, Bogor, Indonesia
Heddy Julistiono: Research Center for Applied Microbiology, National Research and Innovation Agency - BRIN, 16911, Bogor, Indonesia
Bambang Pontjo Priosoeryanto: Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, IPB University, 16680, Bogor, Indonesia
I Made Artika: Department of Biochemistry, Faculty of Mathematics and Natural Sciences, IPB University, 16680, Bogor, Indonesia
Mohd Nazil Salleh: Departnent of Biomedical Sciences, Faculty of Health Sciences, University College of MAIWP International, 68100, Kuala Lumpur, Malaysia

DOI: https://doi.org/10.14716/ijtech.v14i7.6696
Journal volume & issue: Vol. 14, no. 7
pp. 1476 – 1486

Abstract

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Since 2014, we have successfully isolated endophytic fungi from the leaves of Indonesian Annona muricata, exhibiting potential anti-breast cancer properties. The analysis of Internal Transcribed Spacer (ITS) showed the identified fungi species as Phomopsis sp. The ethyl acetate extract derived from Phomopsis sp. inhibited MCF7 cells (IC50

Published in International Journal of Technology

ISSN: 2086-9614 (Print); 2087-2100 (Online)
Publisher: Universitas Indonesia
Country of publisher: Indonesia
LCC subjects: Technology: Technology (General)
Website: http://www.ijtech.eng.ui.ac.id/?id=home

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