Journal of Clinical Medicine (Dec 2023)
Survival and Recurrence of Endocarditis following Mechanical vs. Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data from the INFECT-Registry
- Antonio Salsano,
- Michele Di Mauro,
- Laura Labate,
- Alessandro Della Corte,
- Federica Lo Presti,
- Michele De Bonis,
- Cinzia Trumello,
- Mauro Rinaldi,
- Erik Cura Stura,
- Guglielmo Actis Dato,
- Giuseppe Punta,
- Francesco Nicolini,
- Davide Carino,
- Carlo De Vincentiis,
- Andrea Garatti,
- Giangiuseppe Cappabianca,
- Andrea Musazzi,
- Diego Cugola,
- Maurizio Merlo,
- Davide Pacini,
- Gianluca Folesani,
- Sandro Sponga,
- Igor Vendramin,
- Alberto Pilozzi Casado,
- Francesco Rosato,
- Elisa Mikus,
- Carlo Savini,
- Francesco Onorati,
- Giovanni Battista Luciani,
- Roberto Scrofani,
- Francesco Epifani,
- Francesco Musumeci,
- Antonio Lio,
- Andrea Colli,
- Giosuè Falcetta,
- Salvatore Nicolardi,
- Salvatore Zaccaria,
- Enrico Vizzardi,
- Antonio Pantaleo,
- Giuseppe Minniti,
- Emmanuel Villa,
- Margherita Dalla Tomba,
- Francesco Pollari,
- Fabio Barili,
- Alessandro Parolari,
- Roberto Lorusso,
- Francesco Santini
Affiliations
- Antonio Salsano
- Division of Cardiac Surgery, Ospedale Policlinico San Martino, 16132 Genoa, Italy
- Michele Di Mauro
- CARIM Maastricht University, 6229 ER Maastricht, The Netherlands
- Laura Labate
- Department of Health Sciences (DISSAL), University of Genoa, 16126 Genoa, Italy
- Alessandro Della Corte
- Unit of Cardiac Surgery, Department of Translational Medical Sciences, Monaldi Hospital, University of Campania “L. Vanvitelli”, 80131 Naples, Italy
- Federica Lo Presti
- Unit of Cardiac Surgery, Department of Translational Medical Sciences, Monaldi Hospital, University of Campania “L. Vanvitelli”, 80131 Naples, Italy
- Michele De Bonis
- IRCCS Ospedale San Raffaele, Division of Cardiac Surgery, Università Vita-Salute San Raffaele, 20132 Milan, Italy
- Cinzia Trumello
- IRCCS Ospedale San Raffaele, Division of Cardiac Surgery, Università Vita-Salute San Raffaele, 20132 Milan, Italy
- Mauro Rinaldi
- Cardiac Surgery, Molinette Hospital, University of Turin, 10124 Turin, Italy
- Erik Cura Stura
- Cardiac Surgery, Molinette Hospital, University of Turin, 10124 Turin, Italy
- Guglielmo Actis Dato
- Cardiac Surgery, Mauriziano Hospital, 10128 Turin, Italy
- Giuseppe Punta
- Cardiac Surgery, Mauriziano Hospital, 10128 Turin, Italy
- Francesco Nicolini
- Cardiac Surgery, Maggiore University Hospital, University of Parma, 43121 Parma, Italy
- Davide Carino
- Cardiac Surgery, Maggiore University Hospital, University of Parma, 43121 Parma, Italy
- Carlo De Vincentiis
- Cardiac Surgery, San Donato IRCCS Hospital, San Donato Milanese, 20097 Milan, Italy
- Andrea Garatti
- Cardiac Surgery, San Donato IRCCS Hospital, San Donato Milanese, 20097 Milan, Italy
- Giangiuseppe Cappabianca
- Cardiac Surgery, University Hospital, 21100 Varese, Italy
- Andrea Musazzi
- Cardiac Surgery, University Hospital, 21100 Varese, Italy
- Diego Cugola
- Cardiac Surgery, AO Papa Giovanni XXIII, 24127 Bergamo, Italy
- Maurizio Merlo
- Cardiac Surgery, AO Papa Giovanni XXIII, 24127 Bergamo, Italy
- Davide Pacini
- Cardiac Surgery, S. Orsola-Malpighi University Hospital, University of Bologna, 40126 Bologna, Italy
- Gianluca Folesani
- Cardiac Surgery, S. Orsola-Malpighi University Hospital, University of Bologna, 40126 Bologna, Italy
- Sandro Sponga
- Cardiac Surgery, S. Maria Misericordia Hospital, University of Udine, 33100 Udine, Italy
- Igor Vendramin
- Cardiac Surgery, S. Maria Misericordia Hospital, University of Udine, 33100 Udine, Italy
- Alberto Pilozzi Casado
- Cardiac Surgery, S. Croce Hospital, 12100 Cuneo, Italy
- Francesco Rosato
- Cardiac Surgery, S. Croce Hospital, 12100 Cuneo, Italy
- Elisa Mikus
- GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
- Carlo Savini
- GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy
- Francesco Onorati
- Cardiac Surgery, University Hospital, University of Verona, 37129 Verona, Italy
- Giovanni Battista Luciani
- Cardiac Surgery, University Hospital, University of Verona, 37129 Verona, Italy
- Roberto Scrofani
- Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milano, Italy
- Francesco Epifani
- Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, 20122 Milano, Italy
- Francesco Musumeci
- Cardiac Surgery, San Camillo-Forlanini Hospital, 00152 Rome, Italy
- Antonio Lio
- Cardiac Surgery, San Camillo-Forlanini Hospital, 00152 Rome, Italy
- Andrea Colli
- Cardiac Surgery, AO Pisana University Hospital, University of Pisa, 56126 Pisa, Italy
- Giosuè Falcetta
- Cardiac Surgery, AO Pisana University Hospital, University of Pisa, 56126 Pisa, Italy
- Salvatore Nicolardi
- Cardiac Surgery, Vito Fazzi Hospital, 73100 Lecce, Italy
- Salvatore Zaccaria
- Cardiac Surgery, Vito Fazzi Hospital, 73100 Lecce, Italy
- Enrico Vizzardi
- Cardiology, Spedali Civili Hospital, 25123 Brescia, Italy
- Antonio Pantaleo
- Department of Cardiac Surgery, Azienda ULSS2 Ca’ Foncello Hospital, 31100 Treviso, Italy
- Giuseppe Minniti
- Department of Cardiac Surgery, Azienda ULSS2 Ca’ Foncello Hospital, 31100 Treviso, Italy
- Emmanuel Villa
- Department of Cardiac Surgery, Poliambulanza Foundation Hospital, 25124 Brescia, Italy
- Margherita Dalla Tomba
- Department of Cardiac Surgery, Poliambulanza Foundation Hospital, 25124 Brescia, Italy
- Francesco Pollari
- Cardiac Surgery, Klinikum Nürnberg–Paracelsus Medical University, 90419 Nuremberg, Germany
- Fabio Barili
- Cardiac Surgery, S. Croce Hospital, 12100 Cuneo, Italy
- Alessandro Parolari
- Department of Universitary Cardiac Surgery and Translational Research, IRCCS Policlinico S. Donato, University of Milan, 20122 Milan, Italy
- Roberto Lorusso
- Cardio-Thoracic Surgery Department, Heart & Vascular Centre, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands
- Francesco Santini
- Division of Cardiac Surgery, Ospedale Policlinico San Martino, 16132 Genoa, Italy
- DOI
- https://doi.org/10.3390/jcm13010153
- Journal volume & issue
-
Vol. 13,
no. 1
p. 153
Abstract
Background: Infective endocarditis (IE) is a serious disease, and in many cases, surgery is necessary. Whether the type of prosthesis implanted for aortic valve replacement (AVR) for IE impacts patient survival is a matter of debate. The aim of the present study is to quantify differences in long-term survival and recurrence of endocarditis AVR for IE according to prosthesis type among patients aged 40 to 65 years. Methods: This was an analysis of the INFECT-REGISTRY. Trends in proportion to the use of mechanical prostheses versus biological ones over time were tested by applying the sieve bootstrapped t-test. Confounders were adjusted using the optimal full-matching propensity score. The difference in overall survival was compared using the Cox model, whereas the differences in recurrence of endocarditis were evaluated using the Gray test. Results: Overall, 4365 patients were diagnosed and operated on for IE from 2000 to 2021. Of these, 549, aged between 40 and 65 years, underwent AVR. A total of 268 (48.8%) received mechanical prostheses, and 281 (51.2%) received biological ones. A significant trend in the reduction of implantation of mechanical vs. biological prostheses was observed during the study period (p p = 0.025). Mechanical prostheses were associated with significantly less recurrent endocarditis after AVR than biological prostheses (HR 0.268, 95%CI: 0.077–0.933, p = 0.039). Conclusions: The present analysis of the INFECT-REGISTRY shows increased survival and reduced recurrence of endocarditis after a mechanical aortic valve prosthesis implant for IE in middle-aged patients.
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