Associations of Temporal Cardiometabolic Patterns and Incident SARS-CoV-2 Infection Among U.S. Blood Donors With Serologic Evidence of Vaccination

Elaine A. Yu, PhD; Mars Stone, PhD; Marjorie D. Bravo, MD; Eduard Grebe, PhD; Roberta L. Bruhn, PhD; Marion C. Lanteri, PhD; Mary Townsend, MD; Hany Kamel, MB, BCh; Jefferson M. Jones, MD; Michael P. Busch, MD, PhD; Brian Custer, PhD

AJPM Focus (Apr 2024)

Associations of Temporal Cardiometabolic Patterns and Incident SARS-CoV-2 Infection Among U.S. Blood Donors With Serologic Evidence of Vaccination

Elaine A. Yu, PhD,
Mars Stone, PhD,
Marjorie D. Bravo, MD,
Eduard Grebe, PhD,
Roberta L. Bruhn, PhD,
Marion C. Lanteri, PhD,
Mary Townsend, MD,
Hany Kamel, MB, BCh,
Jefferson M. Jones, MD,
Michael P. Busch, MD, PhD,
Brian Custer, PhD

Affiliations

Elaine A. Yu, PhD: Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Address correspondence to: Elaine A. Yu, PhD, Vitalant Research Institute, 360 Spear Street, Suite 200, San Francisco CA 94105.
Mars Stone, PhD: Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California
Marjorie D. Bravo, MD: Vitalant, Scottsdale, Arizona
Eduard Grebe, PhD: Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California
Roberta L. Bruhn, PhD: Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California
Marion C. Lanteri, PhD: Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Creative Testing Solutions, Tempe, Arizona
Mary Townsend, MD: Vitalant, Scottsdale, Arizona
Hany Kamel, MB, BCh: Vitalant, Scottsdale, Arizona
Jefferson M. Jones, MD: Centers for Disease Control and Prevention, Atlanta, Georgia
Michael P. Busch, MD, PhD: Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Vitalant, Scottsdale, Arizona
Brian Custer, PhD: Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Vitalant, Scottsdale, Arizona

Journal volume & issue: Vol. 3, no. 2
p. 100186

Abstract

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Introduction: Cardiometabolic diseases are associated with greater COVID-19 severity; however, the influences of cardiometabolic health on SARS-CoV-2 infections after vaccination remain unclear. Our objective was to investigate the associations between temporal blood pressure and total cholesterol patterns and incident SARS-CoV-2 infections among those with serologic evidence of vaccination. Methods: In this prospective cohort of blood donors, blood samples were collected in 2020–2021 and assayed for binding antibodies of SARS-CoV-2 nucleocapsid protein antibody seropositivity. We categorized participants into intraindividual pattern subgroups of blood pressure and total cholesterol (persistently, intermittently, or not elevated [systolic blood pressure 0.05). Conclusions: Our findings underscore that the benefits of cardiometabolic health, particularly blood pressure, include a lower risk of SARS-CoV-2 infection after vaccination.

Published in AJPM Focus

ISSN: 2773-0654 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/ajpm-focus

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