Associations of Temporal Cardiometabolic Patterns and Incident SARS-CoV-2 Infection Among U.S. Blood Donors With Serologic Evidence of Vaccination
Elaine A. Yu, PhD,
Mars Stone, PhD,
Marjorie D. Bravo, MD,
Eduard Grebe, PhD,
Roberta L. Bruhn, PhD,
Marion C. Lanteri, PhD,
Mary Townsend, MD,
Hany Kamel, MB, BCh,
Jefferson M. Jones, MD,
Michael P. Busch, MD, PhD,
Brian Custer, PhD
Affiliations
Elaine A. Yu, PhD
Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Address correspondence to: Elaine A. Yu, PhD, Vitalant Research Institute, 360 Spear Street, Suite 200, San Francisco CA 94105.
Mars Stone, PhD
Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California
Marjorie D. Bravo, MD
Vitalant, Scottsdale, Arizona
Eduard Grebe, PhD
Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California
Roberta L. Bruhn, PhD
Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California
Marion C. Lanteri, PhD
Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Creative Testing Solutions, Tempe, Arizona
Mary Townsend, MD
Vitalant, Scottsdale, Arizona
Hany Kamel, MB, BCh
Vitalant, Scottsdale, Arizona
Jefferson M. Jones, MD
Centers for Disease Control and Prevention, Atlanta, Georgia
Michael P. Busch, MD, PhD
Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Vitalant, Scottsdale, Arizona
Brian Custer, PhD
Vitalant Research Institute, San Francisco, California; Department of Laboratory Medicine, University of California San Francisco, San Francisco, California; Vitalant, Scottsdale, Arizona
Introduction: Cardiometabolic diseases are associated with greater COVID-19 severity; however, the influences of cardiometabolic health on SARS-CoV-2 infections after vaccination remain unclear. Our objective was to investigate the associations between temporal blood pressure and total cholesterol patterns and incident SARS-CoV-2 infections among those with serologic evidence of vaccination. Methods: In this prospective cohort of blood donors, blood samples were collected in 2020–2021 and assayed for binding antibodies of SARS-CoV-2 nucleocapsid protein antibody seropositivity. We categorized participants into intraindividual pattern subgroups of blood pressure and total cholesterol (persistently, intermittently, or not elevated [systolic blood pressure 0.05). Conclusions: Our findings underscore that the benefits of cardiometabolic health, particularly blood pressure, include a lower risk of SARS-CoV-2 infection after vaccination.
