N4-Substituted Piperazinyl Norfloxacin Derivatives with Broad-Spectrum Activity and Multiple Mechanisms on Gyrase, Topoisomerase IV, and Bacterial Cell Wall Synthesis

• Ahmed M. Kamal El-sagheir,
• Ireny Abdelmesseh Nekhala,
• Mohammed K. Abd El-Gaber,
• Ahmed S. Aboraia,
• Jonatan Persson,
• Ann-Britt Schäfer,
• Michaela Wenzel,
• Farghaly A. Omar

Affiliations

Ahmed M. Kamal El-sagheir

Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Ireny Abdelmesseh Nekhala

Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden

Mohammed K. Abd El-Gaber

Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Ahmed S. Aboraia

Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Jonatan Persson

Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden

Ann-Britt Schäfer

Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden

Michaela Wenzel

Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden

Farghaly A. Omar

Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt