Communications Biology (Jul 2022)
Mesenchymal stem cells exert renoprotection via extracellular vesicle-mediated modulation of M2 macrophages and spleen-kidney network
- Yuko Shimamura,
- Kazuhiro Furuhashi,
- Akihito Tanaka,
- Munetoshi Karasawa,
- Tomoya Nozaki,
- Shintaro Komatsu,
- Kenshi Watanabe,
- Asuka Shimizu,
- Shun Minatoguchi,
- Makoto Matsuyama,
- Yuriko Sawa,
- Naotake Tsuboi,
- Takuji Ishimoto,
- Hiroshi I. Suzuki,
- Shoichi Maruyama
Affiliations
- Yuko Shimamura
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Kazuhiro Furuhashi
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Akihito Tanaka
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Munetoshi Karasawa
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Tomoya Nozaki
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Shintaro Komatsu
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Kenshi Watanabe
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Asuka Shimizu
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Shun Minatoguchi
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Makoto Matsuyama
- Division of Molecular Genetics, Shigei Medical Research Institute, Minami-ku
- Yuriko Sawa
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Naotake Tsuboi
- Department of Nephrology, Fujita Health University School of Medicine
- Takuji Ishimoto
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- Hiroshi I. Suzuki
- Division of Molecular Oncology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa-ku
- Shoichi Maruyama
- Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Showa-ku
- DOI
- https://doi.org/10.1038/s42003-022-03712-2
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 16
Abstract
The renoprotective effects of adipose-derived mesenchymal stem cells (ASCs) are enhanced through the transfer of EVs predominantly to M2 macrophages in the spleen, providing insights into therapeutic avenues for ASCs.
