Designing HA/PEI nanoparticle composite coating on biodegradable Mg–Zn–Y-Nd alloy to direct cardiovascular cells fate

Abstract

Biodegradable magnesium (Mg) alloy as a new generation of cardiovascular stent material has attracted great attention. However, the problems of excessive degradability and lack of corresponding biological functions of Mg alloys still need to be solved urgently. In the present study, series of hyaluronic acid (HA)/polyethyleneimine (PEI) nanoparticles (NP) with optimized parameters were designed and fixed on the fluorination/poly-dopamine (PDA) treated Mg–Zn–Y-Nd alloy to prepare a multi-functional composite coating. Our data indicated that the HA/PEI NPs composite coatings greatly improved the corrosion resistance and biological functions of the Mg–Zn–Y-Nd alloy. We hope this technology contribute to better feasibility of the new generation of biodegradable Mg alloy stents.

Keywords

• Biodegradable Mg alloy Stent
• Cardiovascular cells fate
• Surface functionalization
• Nanoparticles
• Hyaluronic acid