A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser

Shengsheng Cui; Xinni Pan; Shanshan Fan; Cheng Cao; Yingao Jiao; Yanfei Fu; Jiaqi Niu; Shujin Lin; Jingmao Lao; Yanlei Liu

Materials Today Bio (Apr 2025)

A novel conjugated polymer synthesized via a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser

Shengsheng Cui,
Xinni Pan,
Shanshan Fan,
Cheng Cao,
Yingao Jiao,
Yanfei Fu,
Jiaqi Niu,
Shujin Lin,
Jingmao Lao,
Yanlei Liu

Affiliations

Shengsheng Cui: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China; National Engineering Center for Nanotechnology, Shanghai, 200240, PR China
Xinni Pan: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China
Shanshan Fan: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China
Cheng Cao: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China
Yingao Jiao: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China
Yanfei Fu: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China
Jiaqi Niu: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China
Shujin Lin: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China
Jingmao Lao: Gastrointestinal Surgery, The First People's Hospital of Qinzhou, Qinzhou, 535000, PR China; Corresponding author.
Yanlei Liu: Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China; National Engineering Center for Nanotechnology, Shanghai, 200240, PR China; Corresponding author. Institute of Intelligent Health Diagnosis and Treatment, School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China.

Journal volume & issue: Vol. 31
p. 101488

Abstract

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Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external light irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by the photothermal conversion efficiency of the material. In this study, we developed a novel ladder-type conjugated polymer, PPAPA, via a phenazine ring fusion reaction. PPAPA exhibits a high photothermal conversion efficiency of 75.2 % under 1064 nm laser irradiation, comparable to the benchmark organic photothermal agent SWCNT. Notably, the synthesis of PPAPA avoids the use of noble metal catalysts, eliminating potential biotoxicity caused by residual catalysts and ensuring optimal photothermal stability and efficiency. Furthermore, PPAPA demonstrates efficient photothermal conversion under near-infrared II (NIR-II) 1064 nm laser irradiation, enabling deeper tissue penetration and reduced tissue absorption. This work comprehensively investigates the photothermal properties of PPAPA and evaluates its efficacy in tumor PTT, demonstrating its potential as a novel and effective therapeutic strategy for cancer treatment, offering new hope for patients.

Published in Materials Today Bio

ISSN: 2590-0064 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.journals.elsevier.com/materials-today-bio

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