Current Therapeutic Strategies in Diabetic Foot Ulcers
Aurelio Perez-Favila,
Margarita L Martinez-Fierro,
Jessica G Rodriguez-Lazalde,
Miguel A Cid-Baez,
Michelle de J Zamudio-Osuna,
Ma. del Rosario Martinez-Blanco,
Fabiana E Mollinedo-Montaño,
Iram P Rodriguez-Sanchez,
Rodrigo Castañeda-Miranda,
Idalia Garza-Veloz
Affiliations
Aurelio Perez-Favila
Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico
Margarita L Martinez-Fierro
Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico
Jessica G Rodriguez-Lazalde
Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico
Miguel A Cid-Baez
Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico
Michelle de J Zamudio-Osuna
Bioss Celulas Madre, Av. Gomez Morin No. 1200, Carrizalejo, C.P., San Pedro Garza Garcia 66254, Nuevo Leon, Mexico
Ma. del Rosario Martinez-Blanco
Posgrado en Ingenieria y Tecnologia Aplicada, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Av. Ramon Lopez Velarde No. 801, Col. Centro, C.P., Zacatecas 98000, Mexico
Fabiana E Mollinedo-Montaño
Unidad Academica de Enfermeria, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico
Iram P Rodriguez-Sanchez
Laboratorio de Fisiologia Molecular y Estructural, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, C.P., San Nicolas de los Garza 66455, Nuevo Leon, Mexico
Rodrigo Castañeda-Miranda
Posgrado en Ingenieria y Tecnologia Aplicada, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Av. Ramon Lopez Velarde No. 801, Col. Centro, C.P., Zacatecas 98000, Mexico
Idalia Garza-Veloz
Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico
Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus, with more than 400 million people diagnosed globally, and the condition is responsible for lower extremity amputation in 85% of people affected, leading to high-cost hospital care and increased mortality risk. Neuropathy and peripheral arterial disease trigger deformities or trauma, and aggravating factors such as infection and edema are the etiological factors for the development of DFUs. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk. This review focuses on the current treatment strategies for DFUs with a special emphasis on tissue engineering techniques and regenerative medicine that collectively target all components of chronic wound pathology.
