Journal of Personalized Medicine (Dec 2021)
Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
- Itziar de Rojas,
- Isabel Hernández,
- Laura Montrreal,
- Inés Quintela,
- Miguel Calero,
- Jose Luís Royo,
- Raquel Huerto Vilas,
- Antonio González-Pérez,
- Emilio Franco-Macías,
- Juan Macías,
- Manuel Menéndez-González,
- Ana Frank-García,
- Mónica Diez-Fairen,
- Carmen Lage,
- Sebastián García-Madrona,
- Nuria Aguilera,
- Pablo García-González,
- Raquel Puerta,
- Oscar Sotolongo-Grau,
- Silvia Alonso-Lana,
- Alberto Rábano,
- Alfonso Arias Pastor,
- Ana Belén Pastor,
- Anaïs Corma-Gómez,
- Angel Martín Montes,
- Carmen Martínez Rodríguez,
- Dolores Buiza-Rueda,
- Maria Teresa Periñán,
- Eloy Rodriguez-Rodriguez,
- Ignacio Alvarez,
- Irene Rosas Allende,
- Juan A. Pineda,
- María Bernal Sánchez-Arjona,
- Marta Fernández-Fuertes,
- Silvia Mendoza,
- Teodoro del Ser,
- GR@ACE/DEGESCO Consortium,
- Guillermo Garcia-Ribas,
- Pascual Sánchez-Juan,
- Pau Pastor,
- María J. Bullido,
- Victoria Álvarez,
- Luis M. Real,
- Pablo Mir,
- Gerard Piñol-Ripoll,
- Jose María García-Alberca,
- Miguel Medina,
- Adelina Orellana,
- Chris R. Butler,
- Marta Marquié,
- María Eugenia Sáez,
- Ángel Carracedo,
- Lluís Tárraga,
- Mercè Boada,
- Agustín Ruiz
Affiliations
- Itziar de Rojas
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Isabel Hernández
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Laura Montrreal
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Inés Quintela
- Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain
- Miguel Calero
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Jose Luís Royo
- Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, 29016 Málaga, Spain
- Raquel Huerto Vilas
- Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, 25198 Lleida, Spain
- Antonio González-Pérez
- CAEBI, Centro Andaluz de Estudios Bioinformáticos, 41013 Sevilla, Spain
- Emilio Franco-Macías
- Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain
- Juan Macías
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain
- Manuel Menéndez-González
- Servicio de Neurología, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain
- Ana Frank-García
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Mónica Diez-Fairen
- Fundació Docència i Recerca MútuaTerrassa, 08221 Terrassa, Spain
- Carmen Lage
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Sebastián García-Madrona
- Hospital Universitario Ramon y Cajal, IRYCIS, 28034 Madrid, Spain
- Nuria Aguilera
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Pablo García-González
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Raquel Puerta
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Oscar Sotolongo-Grau
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Silvia Alonso-Lana
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Alberto Rábano
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Alfonso Arias Pastor
- Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, 25198 Lleida, Spain
- Ana Belén Pastor
- CIEN Foundation/Queen Sofia Foundation Alzheimer Center, 28220 Madrid, Spain
- Anaïs Corma-Gómez
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain
- Angel Martín Montes
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Carmen Martínez Rodríguez
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain
- Dolores Buiza-Rueda
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Maria Teresa Periñán
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Eloy Rodriguez-Rodriguez
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Ignacio Alvarez
- Fundació Docència i Recerca MútuaTerrassa, 08221 Terrassa, Spain
- Irene Rosas Allende
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain
- Juan A. Pineda
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain
- María Bernal Sánchez-Arjona
- Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Sevilla, Spain
- Marta Fernández-Fuertes
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain
- Silvia Mendoza
- Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, 29012 Málaga, Spain
- Teodoro del Ser
- Department of Neurology/CIEN Foundation/Queen Sofia Foundation Alzheimer Center, 28220 Madrid, Spain
- GR@ACE/DEGESCO Consortium
- Guillermo Garcia-Ribas
- Hospital Universitario Ramon y Cajal, IRYCIS, 28034 Madrid, Spain
- Pascual Sánchez-Juan
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Pau Pastor
- Fundació Docència i Recerca MútuaTerrassa, 08221 Terrassa, Spain
- María J. Bullido
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Victoria Álvarez
- Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Asturias, Spain
- Luis M. Real
- Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, 41013 Sevilla, Spain
- Pablo Mir
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Gerard Piñol-Ripoll
- Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, 25198 Lleida, Spain
- Jose María García-Alberca
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Miguel Medina
- CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, 28220 Madrid, Spain
- Adelina Orellana
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Chris R. Butler
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Marta Marquié
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- María Eugenia Sáez
- CAEBI, Centro Andaluz de Estudios Bioinformáticos, 41013 Sevilla, Spain
- Ángel Carracedo
- Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, 15705 Santiago de Compostela, Spain
- Lluís Tárraga
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Mercè Boada
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- Agustín Ruiz
- Research Center and Memory Clinic, Ace Alzheimer Center Barcelona—Universitat Internacional de Catalunya, 08017 Barcelona, Spain
- DOI
- https://doi.org/10.3390/jpm11121318
- Journal volume & issue
-
Vol. 11,
no. 12
p. 1318
Abstract
Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.
Keywords
