Plant‐derived peptides for the improvement of Alzheimer's disease: Production, functions, and mechanisms

Like Lin; Cong Li; Tingting Li; Jingyi Zheng; Yu Shu; Jingjing Zhang; Yehua Shen; Difeng Ren

doi:10.1002/fft2.210

Food Frontiers (Jun 2023)

Plant‐derived peptides for the improvement of Alzheimer's disease: Production, functions, and mechanisms

Like Lin,
Cong Li,
Tingting Li,
Jingyi Zheng,
Yu Shu,
Jingjing Zhang,
Yehua Shen,
Difeng Ren

Affiliations

Like Lin: Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials Science National Demonstration Center for Experimental Chemistry Education Northwest University Xi'an Shaanxi China
Cong Li: Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials Science National Demonstration Center for Experimental Chemistry Education Northwest University Xi'an Shaanxi China
Tingting Li: Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials Science National Demonstration Center for Experimental Chemistry Education Northwest University Xi'an Shaanxi China
Jingyi Zheng: Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials Science National Demonstration Center for Experimental Chemistry Education Northwest University Xi'an Shaanxi China
Yu Shu: College of Food Science and Technology Northwest University Xi'an Shaanxi China
Jingjing Zhang: College of Chemical Engineering Northwest University Xi'an Shaanxi China
Yehua Shen: Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials Science National Demonstration Center for Experimental Chemistry Education Northwest University Xi'an Shaanxi China
Difeng Ren: Beijing Key Laboratory of Food Processing and Safety in Forestry Department of Food Science and Engineering, College of Biological Sciences and Biotechnology Beijing Forestry University Beijing China

DOI: https://doi.org/10.1002/fft2.210
Journal volume & issue: Vol. 4, no. 2
pp. 677 – 699

Abstract

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Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset that seriously affects human health. Plant‐derived peptides have been found to hinder the development of AD pathologies, which is an excellent candidate for preventing AD. However, due to the excessively complicated pathogenesis of AD and the fact that most studies on the activity of plant‐derived peptides are single and not deep enough, which restricted the development and application of plant‐derived AD‐prevention peptides (PADPs). This review summarized the currently available means of obtaining PADPs, in vitro and in vivo AD‐prevention activity validation protocols, molecular pathways of PADPs, the structure–activity relationship between plant‐derived peptides and AD‐prevention activity, and some perspectives of current advanced technologies. This paper will help to develop the foundation for the production and exploitation of PADPs.

Published in Food Frontiers

ISSN: 2643-8429 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply; Technology: Chemical technology: Food processing and manufacture
Website: https://onlinelibrary.wiley.com/journal/26438429

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