Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates

Nik Franko; Ana Palma Teixeira; Shuai Xue; Ghislaine Charpin-El Hamri; Martin Fussenegger

doi:10.1038/s41467-021-27072-3

Nature Communications (Nov 2021)

Design of modular autoproteolytic gene switches responsive to anti-coronavirus drug candidates

Nik Franko,
Ana Palma Teixeira,
Shuai Xue,
Ghislaine Charpin-El Hamri,
Martin Fussenegger

Affiliations

Nik Franko: ETH Zurich, Department of Biosystems Science and Engineering
Ana Palma Teixeira: ETH Zurich, Department of Biosystems Science and Engineering
Shuai Xue: ETH Zurich, Department of Biosystems Science and Engineering
Ghislaine Charpin-El Hamri: Département Génie Biologique, Institut Universitaire de Technologie
Martin Fussenegger: ETH Zurich, Department of Biosystems Science and Engineering

DOI: https://doi.org/10.1038/s41467-021-27072-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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SARS-CoV-2 proteases are key targets for anti-viral drug development. Here the authors present modular tunable autoproteolytic gene switches for virus free cell culture screening of inhibitors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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