Dataset of liver proteins changed in eu- and hypothyroid female rats upon in vivo exposure to hexabromocyclododecane (HBCD)
I. Miller,
T. Serchi,
S. Cambier,
C. Diepenbroek,
J. Renaut,
J.H.J. van den Berg,
C. Kwadijk,
A.C. Gutleb,
E. Rijntjes,
A.J. Murk
Affiliations
I. Miller
Institute for Medical Biochemistry, Department for Biomedical Sciences, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A-1210 Vienna, Austria; Corresponding author.
T. Serchi
Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 5, avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Grand-duchy of Luxembourg
S. Cambier
Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 5, avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Grand-duchy of Luxembourg
C. Diepenbroek
Wageningen University, Human and Animal Physiology, P.O. Box 338, 6700 AH Wageningen, The Netherlands
J. Renaut
Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 5, avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Grand-duchy of Luxembourg
J.H.J. van den Berg
Wageningen University, Division of Toxicology, Tuinlaan 5, 6703HE Wageningen, The Netherlands
C. Kwadijk
Wageningen Institute for Marine Resources & Ecosystem Studies, IMARES, IJmuiden, The Netherlands
A.C. Gutleb
Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 5, avenue des Hauts-Fourneaux, L-4362 Esch-sur-Alzette, Grand-duchy of Luxembourg
E. Rijntjes
Wageningen University, Human and Animal Physiology, P.O. Box 338, 6700 AH Wageningen, The Netherlands; Charité-Universitätsmedizin Berlin, Institute for Experimental Endocrinology, Augustenburger Platz 1, 13353, Berlin, Germany
A.J. Murk
Wageningen University, Division of Toxicology, Tuinlaan 5, 6703HE Wageningen, The Netherlands
Female Wistar rats with different thyroid status (eu-, hypothyroid) were exposed to 0, 3 or 30 mg/kg body weight of the flame retardant HBCD for 7 days. Changes in protein patterns obtained by 2D-DIGE were evaluated, and different animal groups compared taking into account their exposure and thyroid status. Proteins significantly altered in abundance in any of these comparisons were identified by mass spectrometry. These data, together with hormone data of the animals, are discussed in “Hexa-bromocyclododecane (HBCD) induced changes in the liver proteome of eu- and hypothyroid female rats” (Miller et al., 2016) [1]. Keywords: HBCD, Proteomics, Rat, Liver, Hypothyroidism, Lipid metabolism
