Difference of DNA Compaction Performed by Two kinds of Oncopterin-Mimic Pteridine - Polyamine Conjugates

Murata Shizuaki; Chen Ning

doi:10.1515/pteridines.2006.17.1.1

Pteridines (Feb 2006)

Difference of DNA Compaction Performed by Two kinds of Oncopterin-Mimic Pteridine - Polyamine Conjugates

Murata Shizuaki,
Chen Ning

Affiliations

Murata Shizuaki: Graduate School of Environmental Studies, Nagoya University, Chikusa Nagoya, 464-8601 Japan, Fax: +81 52 789 4765
Chen Ning: Department of Physics, Kyoto University, Sakyo, 608-8501 Japan

DOI: https://doi.org/10.1515/pteridines.2006.17.1.1
Journal volume & issue: Vol. 17, no. 1
pp. 1 – 4

Abstract

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Two types of pteridine - polyamine conjugates designed on oncopterin perform different actions to DNA. The most obvious difference is their actions in DNA compaction. One of the pteridine - polyamine conjugates, PT- 2R, containing a polyamine substituent (R) on the C(2) position of pterin (PT) compacts a DNA molcculc in an all-or-none fashion without the intervention of an intermediate. The othcr (PT-4R: R exists on the c(4) position of PT) carries out the DNA compaction via partially compacted intermediates. The difference is discussed based on various interaction modes of the pteridine - polyamine conjugates to DNA.

Published in Pteridines

ISSN: 0933-4807 (Print); 2195-4720 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry: Crystallography
Website: https://www.degruyter.com/view/j/pteridines

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