Research progress in degradation behavior of biodegradable medical Mg-based alloys <i>in vivo</i> and <i>in vitro</i>

Abstract

As a new generation of medical degradable biomaterials, magnesium alloys were known as "revolutionary medical metal materials" due to their good biocompatibility, unique degradability and excellent mechanical transmission. However, the corrosion resistance of magnesium alloys is poor and there are phenomena such as rapid and uneven degradation.The research progress in improving the degradation properties of magnesium alloys was introduced from four aspects: microalloying, heat treatment process, plastic deformation and surface modification. The degradation rate and degradation modes of medical magnesium alloys in vivo and in vitro under different processing methods were compared. The influence of microstructure evolution and film characteristics of magnesium alloys under different processing conditions on the destruction mechanism of the Cl- for the film layer and the three-dimensional degradation morphology were revealed.The correlation data analysis model between different process conditions and corrosion degradation rate of magnesium alloys in simulated solution was established.Finally, it was pointed out that the focus of future research in this field is to analyse the main action mechanism of microstructure on magnesium alloys degradation properties from multiple perspectives and to build a prediction model of microstructure on magnesium alloys degradation life.

Keywords

• degradable mg alloy
• degradation <i>in vivo</i>
• degradation <i>in vitro</i>
• degradation rate
• film layer feature