Regulatory control of DNA end resection by Sae2 phosphorylation

Elda Cannavo; Dominic Johnson; Sara N. Andres; Vera M. Kissling; Julia K. Reinert; Valerie Garcia; Dorothy A. Erie; Daniel Hess; Nicolas H. Thomä; Radoslav I. Enchev; Matthias Peter; R. Scott Williams; Matt J. Neale; Petr Cejka

doi:10.1038/s41467-018-06417-5

Nature Communications (Oct 2018)

Regulatory control of DNA end resection by Sae2 phosphorylation

Elda Cannavo,
Dominic Johnson,
Sara N. Andres,
Vera M. Kissling,
Julia K. Reinert,
Valerie Garcia,
Dorothy A. Erie,
Daniel Hess,
Nicolas H. Thomä,
Radoslav I. Enchev,
Matthias Peter,
R. Scott Williams,
Matt J. Neale,
Petr Cejka

Affiliations

Elda Cannavo: Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI)
Dominic Johnson: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Sara N. Andres: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Department of Health and Human Services, US National Institutes of Health
Vera M. Kissling: Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH)
Julia K. Reinert: Friedrich Miescher Institute for Biomedical Research
Valerie Garcia: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Dorothy A. Erie: Department of Chemistry, Lineberger Comprehensive Cancer Center, University of North Carolina
Daniel Hess: Friedrich Miescher Institute for Biomedical Research
Nicolas H. Thomä: Friedrich Miescher Institute for Biomedical Research
Radoslav I. Enchev: Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH)
Matthias Peter: Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH)
R. Scott Williams: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Department of Health and Human Services, US National Institutes of Health
Matt J. Neale: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Petr Cejka: Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI)

DOI: https://doi.org/10.1038/s41467-018-06417-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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