Trafficking and effect of released DNA on cGAS-STING signaling pathway and cardiovascular disease

Zimo Zhou; Zimo Zhou; Changhan Ou-yang; Changhan Ou-yang; Qingjie Chen; Qingjie Chen; Zhanhong Ren; Zhanhong Ren; Xiying Guo; Xiying Guo; Min Lei; Min Lei; Chao Liu; Chao Liu; Xiaosong Yang; Xiaosong Yang

doi:10.3389/fimmu.2023.1287130

Frontiers in Immunology (Dec 2023)

Trafficking and effect of released DNA on cGAS-STING signaling pathway and cardiovascular disease

Zimo Zhou,
Zimo Zhou,
Changhan Ou-yang,
Changhan Ou-yang,
Qingjie Chen,
Qingjie Chen,
Zhanhong Ren,
Zhanhong Ren,
Xiying Guo,
Xiying Guo,
Min Lei,
Min Lei,
Chao Liu,
Chao Liu,
Xiaosong Yang,
Xiaosong Yang

Affiliations

Zimo Zhou: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Zimo Zhou: State Key Laboratory of Trauma, Burns and Combined Injury, College of Preventive Medicine, Army Medical University, Chongqing, China
Changhan Ou-yang: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Changhan Ou-yang: Xianning Medical College, Hubei University of Science and Technology, Xianning, China
Qingjie Chen: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Qingjie Chen: Xianning Medical College, Hubei University of Science and Technology, Xianning, China
Zhanhong Ren: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Zhanhong Ren: Xianning Medical College, Hubei University of Science and Technology, Xianning, China
Xiying Guo: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Xiying Guo: Xianning Medical College, Hubei University of Science and Technology, Xianning, China
Min Lei: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Min Lei: Xianning Medical College, Hubei University of Science and Technology, Xianning, China
Chao Liu: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Chao Liu: Xianning Medical College, Hubei University of Science and Technology, Xianning, China
Xiaosong Yang: Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, China
Xiaosong Yang: Xianning Medical College, Hubei University of Science and Technology, Xianning, China

DOI: https://doi.org/10.3389/fimmu.2023.1287130
Journal volume & issue: Vol. 14

Abstract

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Evidence from clinical research and animal studies indicates that inflammation is an important factor in the occurrence and development of cardiovascular disease (CVD). Emerging evidence shows that nucleic acids serve as crucial pathogen-associated molecular patterns (PAMPs) or non-infectious damage-associated molecular patterns (DAMPs), are released and then recognized by pattern recognition receptors (PRRs), which activates immunological signaling pathways for host defense. Mechanistically, the released nucleic acids activate cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING) to promote type I interferons (IFNs) production, which play an important regulatory function during the initiation of an innate immune response to various diseases, including CVD. This pathway represents an essential defense regulatory mechanism in an organism’s innate immune system. In this review, we outline the overall profile of cGAS-STING signaling, summarize the latest findings on nucleic acid release and trafficking, and discuss their potential role in CVD. This review also sheds light on potential directions for future investigations on CVD.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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