Nature Communications (Jun 2021)

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

  • Fan Yang,
  • Zhenqiang He,
  • Hao Duan,
  • Duo Zhang,
  • Juehui Li,
  • Huijuan Yang,
  • Jay F. Dorsey,
  • Wei Zou,
  • S. Ali Nabavizadeh,
  • Stephen J. Bagley,
  • Kalil Abdullah,
  • Steven Brem,
  • Lin Zhang,
  • Xiaowei Xu,
  • Katelyn T. Byrne,
  • Robert H. Vonderheide,
  • Yanqing Gong,
  • Yi Fan

DOI
https://doi.org/10.1038/s41467-021-23832-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Glioblastomas are generally resistant to treatment with immune checkpoint inhibitors. Here the authors show that IL6 blockade, in combination with a CD40 agonist, overcomes macrophage-mediated immunosuppression and sensitizes glioblastoma to immune checkpoint blockade in preclinical models.