BMJ Open (Jun 2024)
Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry
- Barbara E Wildhaber,
- Wei Zhang,
- Martin de Santibañes,
- Victoria Ardiles,
- Xueli Bai,
- Mukesh Kumar,
- Mohamed Rela,
- Reinoud P H Bokkers,
- Ekkehard Sturm,
- Simon McGuirk,
- Girish Gupte,
- Esteban Frauca,
- Francisco Hernández-Oliveros,
- Winita Hardikar,
- Helen Evans,
- Khalid Sharif,
- Jiří Froněk,
- David Duncan,
- Emmanuel Gonzales,
- Carl Jorns,
- Alessandro Parente,
- Ulrich Baumann,
- Lidia Monti,
- Marco Spada,
- Denise Aldrian,
- Hubert P J van der Doef,
- Thomas Casswall,
- Martin Delle,
- Georg F Vogel,
- Adam Kolesnik,
- Mauricio Larrarte K,
- Paolo Marra,
- Michela Bravi,
- Domenico Pinelli,
- Hajime Uchida,
- Vidyadhar Mali,
- Marion Aw,
- Stéphanie Franchi-Abella,
- Florent Guérin,
- Julia Minetto,
- Sergio Sierre,
- Jimmy Walker Uno,
- Steffen Hartleif,
- Cristina T Ferreira,
- Luiza S Nader,
- Catalina Jaramillo,
- Amit A Shah,
- Michael R Acord,
- Tommaso Alterio,
- Marisa Beretta,
- Haritha Rajakrishnan,
- Sudhindran Surendran,
- Weihao Li,
- Marcelo Dip,
- Sue Bates,
- Lynette Goh,
- Jonathan Seisenbacher,
- Joao Seda Neto,
- Eduardo Antunes da Fonseca,
- Carolina Magalhães Costa,
- Marco A Farina,
- Khaled Z Dajani,
- David L Bigam,
- Ting-Bo Liang,
- Lucie Gonsorčíková,
- Šimon Bohuš,
- Norman Junge,
- Nicolas Richter,
- Muthukumarassamy Rajakannu,
- Kumar Palaniappan,
- Arti Pawaria,
- Shaleen Agarwal,
- Subhash Gupta,
- Sonal Asthana,
- Vaishnavi Bandewar,
- Karthik Raichurkar,
- Yusuke Yanagi,
- Ryuji Komine,
- Peter Carr-Boyd,
- Marek Stefanowicz,
- Julita Latka-Grot,
- Dieter C Broering,
- Dimitri A Raptis,
- Kris Ann H Marquez,
- Francisca Van der Schyff,
- Jesús Quintero-Bernabeu,
- Maria Mercadal-Hally,
- Ane M Andres,
- Riccardo Superina,
- Juan Carlos Caicedo,
- Leandra Bitterfeld,
- Zachary Kastenberg,
- Bryanna Domenick,
- George V Mazariegos,
- Kyle Soltys,
- Joseph DiNorcia,
- Swanti Antala,
- Sander S Florman,
- Bettina M Buchholz,
- Uta Herden,
- Lutz Fischer,
- Rudi A J O Dierckx,
- Hermien Hartog
Affiliations
- Barbara E Wildhaber
- Swiss Paediatric Liver Centre, Division of Child and Adolescent Surgery, Geneva University Hospitals, Geneve, Switzerland
- Wei Zhang
- 18 Department of Hepatobiliary and Pancreatic Surgery, Liver Transplant Center, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China
- Martin de Santibañes
- HPB and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
- Victoria Ardiles
- HPB and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
- Xueli Bai
- 18 Department of Hepatobiliary and Pancreatic Surgery, Liver Transplant Center, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China
- Mukesh Kumar
- 30 Centre for Liver and Biliary Sciences, Max Super Speciality Hospital Saket, New Delhi, Delhi, India
- Mohamed Rela
- 27 Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
- Reinoud P H Bokkers
- Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands
- Ekkehard Sturm
- Paediatric Gastroenterology and Hepatology, University Hospitals Tubingen, Tubingen, Germany
- Simon McGuirk
- Department of Interventional Radiology, Birmingham Women’s and Children’s Hospitals NHS Foundation Trust, Birmingham, UK
- Girish Gupte
- Liver Unit, Birmingham Women’s and Children’s Hospitals NHS Foundation Trust, Birmingham, UK
- Esteban Frauca
- 48 Pediatric Hepatology Department, La Paz University Hospital, Madrid, Madrid, Spain
- Francisco Hernández-Oliveros
- 47 Pediatric Surgery Department, La Paz University Hospital, Madrid, Madrid, Spain
- Winita Hardikar
- Department of Pediatrics, Royal Children`s Hospital Research Institute, Parkville, Victoria, Australia
- Helen Evans
- 37 Department of Paediatric Gastroenterology, Starship Children`s Health, Auckland, New Zealand
- Khalid Sharif
- Liver Unit, Birmingham Women’s and Children’s Hospitals NHS Foundation Trust, Birmingham, UK
- Jiří Froněk
- 20 Department of Transplant Surgery, Institute of Clinical and Experimental medicine, Praha, Czech Republic
- David Duncan
- 39 Department of Interventional Radiology, Auckland City Hospital, Auckland, Auckland, New Zealand
- Emmanuel Gonzales
- Paediatric Hepatology and Paediatric Liver Transplantation Unit, Hôpital Bicêtre, Paris, France
- Carl Jorns
- 50 Division for Transplantation Surgery, Department Clinical Interventions and Technology CLINTEC, Karolinska Institute, Stockholm, Sweden
- Alessandro Parente
- 17 Department of Surgery, Division of Transplantation Surgery, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada
- Ulrich Baumann
- 24 Division for Pediatric Gastroenterology and Hepatology, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
- Lidia Monti
- 33 Gastrointestinal and Transplanted Liver Imaging Unit, Ospedale Pediatrico Bambino Gesù, Roma, Italy
- Marco Spada
- 32 Division of Hepatobiliopancreatic Surgery, Liver and Kidney Transplantion, Ospedale Pediatrico Bambino Gesu, Roma, Italy
- Denise Aldrian
- Department of Paediatrics, Medical University of Innsbruck, Innsbruck, Austria
- Hubert P J van der Doef
- Division of Paediatric Gastroenterology and Hepatology, Department of Paediatrics, University Medical Centre Groningen, Groningen, The Netherlands
- Thomas Casswall
- Department Clinical Interventions and Technology Clintec, Division for Paediatrics, Karolinska Institute, Stockholm, Sweden
- Martin Delle
- Department Clinical Science, Intervention and Technology Clintec, Division for Interventional Radiology, Karolinska Institute, Stockholm, Sweden
- Georg F Vogel
- Department of Paediatrics, Medical University of Innsbruck, Innsbruck, Austria
- Adam Kolesnik
- Cardiovascular Interventions Laboratory, The Children’s Memorial Health Institute, Warsaw, Poland
- Mauricio Larrarte K
- Department of Paediatric Gastroenterology, Hepatology and Nutrition, Vall d’Hebron Hospital (HVH), Barcelona, Spain
- Paolo Marra
- Department of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy
- Michela Bravi
- Department of Paediatric Hepatology, Gastroenterology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy
- Domenico Pinelli
- Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy
- Hajime Uchida
- Organ Transplantation Centre, National Center for Child Health and Development, Tokyo, Japan
- Vidyadhar Mali
- Department of Paediatric Surgery, National University Hospital, Singapore
- Marion Aw
- Department of Paediatrics, National University Hospital, Singapore
- Stéphanie Franchi-Abella
- Department of Paediatric Radiology, Hôpital Bicêtre, Paris, France
- Florent Guérin
- Paediatric Surgery and Paediatric Liver Transplantation Unit, Hôpital Bicêtre, Paris, France
- Julia Minetto
- Division of Liver Transplant, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina
- Sergio Sierre
- Division of Interventional Radiology, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina
- Jimmy Walker Uno
- HPB and Liver Transplant Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
- Steffen Hartleif
- Paediatric Gastroenterology and Hepatology, University Hospitals Tubingen, Tubingen, Germany
- Cristina T Ferreira
- Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil
- Luiza S Nader
- Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil
- Catalina Jaramillo
- Department of Paediatrics, Division of Paediatric Gastroenterology, Hepatology and Nutrition, The University of Utah School of Medicine, Salt Lake City, Utah, USA
- Amit A Shah
- Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- Michael R Acord
- Department of Radiology, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- Tommaso Alterio
- Gastrointestinal, Liver, Nutrition Disorders Unit, IRCCS Pediatric Hospital Bambino Gesù, Rome, Italy
- Marisa Beretta
- Faculty of Health Sciences, Wits Donald Gordon Medical Centre, Johannesburg, South Africa
- Haritha Rajakrishnan
- 29 Department of Solid organ transplantation, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India
- Sudhindran Surendran
- 29 Department of Solid organ transplantation, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, India
- Weihao Li
- 1 Department of Radiology, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands
- Marcelo Dip
- 8 Division of Liver Transplant, Hospital de Pediatría Prof Dr Juan P Garrahan, Buenos Aires, Argentina
- Sue Bates
- 11 Department of Gastroenterology, The Royal Children`s Hospital Melbourne, Melbourne, Victoria, Australia
- Lynette Goh
- 11 Department of Gastroenterology, The Royal Children`s Hospital Melbourne, Melbourne, Victoria, Australia
- Jonathan Seisenbacher
- 12 Department of Paediatrics I, Medical University of Innsbruck, Innsbruck, Austria
- Joao Seda Neto
- 14 Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Sao Paulo, Brazil
- Eduardo Antunes da Fonseca
- 14 Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Sao Paulo, Brazil
- Carolina Magalhães Costa
- 14 Hepatology and Liver Transplantation, Hospital Sírio-Libanês, Sao Paulo, Brazil
- Marco A Farina
- 16 Department of Paediatrics, Hospital Santo Antonio, Porto Alegre, Brazil
- Khaled Z Dajani
- 17 Department of Surgery, Division of Transplantation Surgery, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada
- David L Bigam
- 17 Department of Surgery, Division of Transplantation Surgery, University of Alberta Faculty of Medicine & Dentistry, Edmonton, Alberta, Canada
- Ting-Bo Liang
- 18 Department of Hepatobiliary and Pancreatic Surgery, Liver Transplant Center, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China
- Lucie Gonsorčíková
- 19 Department of Pediatrics, First Faculty of Medicine, Thomayer University Hospital, Praha, Czech Republic
- Šimon Bohuš
- 19 Department of Pediatrics, First Faculty of Medicine, Thomayer University Hospital, Praha, Czech Republic
- Norman Junge
- 24 Division for Pediatric Gastroenterology and Hepatology, Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany
- Nicolas Richter
- 25 Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany
- Muthukumarassamy Rajakannu
- 27 Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
- Kumar Palaniappan
- 27 Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India
- Arti Pawaria
- 28 Department of Pediatric Hepatology & Gastroenterology, Amrita Institute of Medical Sciences & Research Centre, New Delhi, Delhi, India
- Shaleen Agarwal
- 30 Centre for Liver and Biliary Sciences, Max Super Speciality Hospital Saket, New Delhi, Delhi, India
- Subhash Gupta
- 30 Centre for Liver and Biliary Sciences, Max Super Speciality Hospital Saket, New Delhi, Delhi, India
- Sonal Asthana
- 31 Integrated Liver Care Department, Aster CMI Hospital, Bengaluru, Karnataka, India
- Vaishnavi Bandewar
- 31 Integrated Liver Care Department, Aster CMI Hospital, Bengaluru, Karnataka, India
- Karthik Raichurkar
- 31 Integrated Liver Care Department, Aster CMI Hospital, Bengaluru, Karnataka, India
- Yusuke Yanagi
- 35 Organ Transplantation Center, National Center for Child Health and Development, Setagaya-ku, Japan
- Ryuji Komine
- 35 Organ Transplantation Center, National Center for Child Health and Development, Setagaya-ku, Japan
- Peter Carr-Boyd
- 38 New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, Auckland, New Zealand
- Marek Stefanowicz
- 40 Department of Pediatric Surgery and Organ Transplantation, Children`s Memorial Health Institute, Warszawa, Poland
- Julita Latka-Grot
- 40 Department of Pediatric Surgery and Organ Transplantation, Children`s Memorial Health Institute, Warszawa, Poland
- Dieter C Broering
- 41 Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
- Dimitri A Raptis
- 41 Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
- Kris Ann H Marquez
- 41 Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
- Francisca Van der Schyff
- 45 Department of surgery, Wits Donald Gordon Medical Centre, Johannesburg, South Africa
- Jesús Quintero-Bernabeu
- 46 Pediatric Hepatology and Liver Trasplant Department, Vall d`Hebron University Hospital, Barcelona, Spain
- Maria Mercadal-Hally
- 46 Pediatric Hepatology and Liver Trasplant Department, Vall d`Hebron University Hospital, Barcelona, Spain
- Ane M Andres
- 47 Pediatric Surgery Department, La Paz University Hospital, Madrid, Madrid, Spain
- Riccardo Superina
- 54 Division of Transplant and Advanced Hepatobiliary Surgery, Ann and Robert H Lurie Children`s Hospital of Chicago, Chicago, Illinois, USA
- Juan Carlos Caicedo
- 55 Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
- Leandra Bitterfeld
- 57 Intermountain Primary Children`s Hospital, Salt Lake City, Utah, USA
- Zachary Kastenberg
- 58 Department of Surgery, Division of Paediatric Surgery, University of Utah, Primary Children`s Hospital, Salt Lake City, Utah, USA
- Bryanna Domenick
- 59 Division of Gastroenterology, Hepatology and Nutrition, Department of Paediatrics, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
- George V Mazariegos
- 61 Children`s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
- Kyle Soltys
- 61 Children`s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
- Joseph DiNorcia
- 62 Recanati-Miller Transplantation Institute, Mount Sinai Hospital, Los Angeles, California, USA
- Swanti Antala
- 62 Recanati-Miller Transplantation Institute, Mount Sinai Hospital, Los Angeles, California, USA
- Sander S Florman
- 62 Recanati-Miller Transplantation Institute, Mount Sinai Hospital, Los Angeles, California, USA
- Bettina M Buchholz
- 63 Department of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Uta Herden
- 63 Department of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Lutz Fischer
- 63 Department of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Rudi A J O Dierckx
- 64 Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Centre Groningen, Groningen, The Netherlands
- Hermien Hartog
- 65 Department of Surgery, Section of Hepatobiliary Surgery & Liver Transplantation, University Medical Centre Groningen, Groningen, The Netherlands
- DOI
- https://doi.org/10.1136/bmjopen-2023-081933
- Journal volume & issue
-
Vol. 14,
no. 6
Abstract
Introduction Hepatic artery complications (HACs), such as a thrombosis or stenosis, are serious causes of morbidity and mortality after paediatric liver transplantation (LT). This study will investigate the incidence, current management practices and outcomes in paediatric patients with HAC after LT, including early and late complications.Methods and analysis The HEPatic Artery stenosis and Thrombosis after liver transplantation In Children (HEPATIC) Registry is an international, retrospective, multicentre, observational study. Any paediatric patient diagnosed with HAC and treated for HAC (at age <18 years) after paediatric LT within a 20-year time period will be included. The primary outcomes are graft and patient survivals. The secondary outcomes are technical success of the intervention, primary and secondary patency after HAC intervention, intraprocedural and postprocedural complications, description of current management practices, and incidence of HAC.Ethics and dissemination All participating sites will obtain local ethical approval and (waiver of) informed consent following the regulations on the conduct of observational clinical studies. The results will be disseminated through scientific presentations at conferences and through publication in peer-reviewed journals.Trial registration number The HEPATIC registry is registered at the ClinicalTrials.gov website; Registry Identifier: NCT05818644.
