Nature Communications (Oct 2022)
GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation
- Tai-Ying Chu,
- Céline Zheng-Gérard,
- Kuan-Yeh Huang,
- Yu-Chi Chang,
- Ying-Wen Chen,
- Kuan-Yu I,
- Yu-Ling Lo,
- Nien-Yi Chiang,
- Hsin-Yi Chen,
- Martin Stacey,
- Siamon Gordon,
- Wen-Yi Tseng,
- Chiao-Yin Sun,
- Yen-Mu Wu,
- Yi-Shin Pan,
- Chien-Hao Huang,
- Chun-Yen Lin,
- Tse-Ching Chen,
- Kamel El Omari,
- Marilina Antonelou,
- Scott R. Henderson,
- Alan Salama,
- Elena Seiradake,
- Hsi-Hsien Lin
Affiliations
- Tai-Ying Chu
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Céline Zheng-Gérard
- Department of Biochemistry, University of Oxford
- Kuan-Yeh Huang
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Yu-Chi Chang
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Ying-Wen Chen
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Kuan-Yu I
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Yu-Ling Lo
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Nien-Yi Chiang
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Hsin-Yi Chen
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Martin Stacey
- Faculty of Biological Sciences, School of Molecular and Cellular Biology, University of Leeds
- Siamon Gordon
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- Wen-Yi Tseng
- Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital-Keelung
- Chiao-Yin Sun
- Department of Nephrology, Chang Gung Memorial Hospital-Keelung
- Yen-Mu Wu
- Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University
- Yi-Shin Pan
- Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital-Linkou
- Chien-Hao Huang
- Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital-Linkou
- Chun-Yen Lin
- Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital-Linkou
- Tse-Ching Chen
- Department of Anatomic Pathology, Chang Gung Memorial Hospital-Linkou
- Kamel El Omari
- Diamond Light Source Limited, Harwell Science and Innovation Campus
- Marilina Antonelou
- Department of Renal Medicine, Royal Free Campus, UCL
- Scott R. Henderson
- Department of Renal Medicine, Royal Free Campus, UCL
- Alan Salama
- Department of Renal Medicine, Royal Free Campus, UCL
- Elena Seiradake
- Department of Biochemistry, University of Oxford
- Hsi-Hsien Lin
- Department of Microbiology and Immunology, College of Medicine, Chang Gung University
- DOI
- https://doi.org/10.1038/s41467-022-34083-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Activation of neutrophil leukocytes is tightly regulated, and it is important to understand the molecular mechanisms of their response to physiological and pathological stimuli. Here authors show that the adhesion molecule G protein-coupled receptor 97 and its interaction partners play pivotal roles in neutrophil leukocyte activation both in anti-microbial response and in inflammatory diseases.
