A green approach for the synthesis of 2-substituted benzoxazoles and benzothiazoles via coupling/cyclization reactions
Hai Truong Nguyen,
Trinh Hao Nguyen,
Dung Duc Pham,
Cong Tien Nguyen,
Phuong Hoang Tran
Affiliations
Hai Truong Nguyen
Department of Organic Chemistry, Faculty of Chemistry, University of Science, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet Nam
Trinh Hao Nguyen
Department of Organic Chemistry, Faculty of Chemistry, University of Science, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet Nam
Dung Duc Pham
Faculty of Chemistry, Ho Chi Minh City University of Education, Viet Nam; Corresponding author.
Cong Tien Nguyen
Faculty of Chemistry, Ho Chi Minh City University of Education, Viet Nam
Phuong Hoang Tran
Department of Organic Chemistry, Faculty of Chemistry, University of Science, Ho Chi Minh City, Viet Nam; Vietnam National University, Ho Chi Minh City, Viet Nam; Corresponding author.
We have developed the green method for the synthesis of benzoxazoles and benzothiazoles with moderate to good yields using imidazolium chlorozincate (II) ionic liquid supported into Fe3O4 nanoparticles (LAIL@MNP) under solvent-free sonication. The reaction was performed under mild conditions and only produced water as a sole byproduct. The reactions under solvent-free sonication showed advantages of faster reaction rate (30 min) and high yields of the products (up to 90%). Moreover, the LAIL@MNP material was easily separated from the reaction mixture and can be recycled for five consecutive runs with a slight decrease in its catalytic performance (from 82 to 73%).
