Nature Communications (May 2020)

Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes

  • M. Fatih Abasıyanık,
  • Krysta Wolfe,
  • Hoang Van Phan,
  • Jing Lin,
  • Bharathi Laxman,
  • Steven R. White,
  • Philip A. Verhoef,
  • Gökhan M. Mutlu,
  • Bhakti Patel,
  • Savaş Tay

DOI
https://doi.org/10.1038/s41467-020-16124-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Ultrasensitive methods for detection of biomarkers for infectious disease are needed for diagnosing, monitoring and targeting treatment. Here the authors develop a digital assay for inflammatory markers, bacterial DNA and antibotic-resistance genes and apply it to characterise asthma patients and predict mortality from septic shock.