Unveiling a Dermatological Rarity: The Enigma of Vulvar Intraepithelial Neoplasia Grade III (HSIL) and the Role of p53 in Its Development
Piotr Brzeziński,
Igor Feszak,
Beatriz Di Martino Ortiz,
Sylwia Feszak,
Piotr Kawczak,
Tomasz Bączek
Affiliations
Piotr Brzeziński
Institute of Health Sciences, Pomeranian University in Słupsk, 76-200 Słupsk, Poland
Igor Feszak
Institute of Health Sciences, Pomeranian University in Słupsk, 76-200 Słupsk, Poland
Beatriz Di Martino Ortiz
Dermatology Department, Clinicas Hospital, Faculty of Medical Sciences, National University of Ausunción, San Lorenzo 111421, Paraguay
Sylwia Feszak
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, ul. Unii Lubelskiej 1, 71-252 Szczecin, Poland
Piotr Kawczak
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland
Tomasz Bączek
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland
Vulvar intraepithelial neoplasia, also known as VIN, is a non-invasive squamous lesion and precursor of squamous cell carcinoma (SCC) of the vulva. There is no screening test for vulvar intraepithelial neoplasia. Diagnosis of VIN is made clinically and confirmed with a biopsy. We describe a 66-year-old woman with a condyloma-like tumour located in the skin on the vestibule of the vagina. A biopsy sample was taken from the nodule. The definitive diagnosis is supported by the histological examination (VIN III) and immunohistochemical examination of p16(+), p53(+), and a few cell nuclei. The case provides information on the importance of multidisciplinary cooperation. Lifelong surveillance is essential since the resection of individual lesions does not guarantee the prevention of invasive cancer.
