Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves

Abstract

It is unclear what role calcium signalling plays in the Drosophila wing disc. Here, the authors show that on mechanical stress, slow, long-range intercellular calcium waves are initiated in vivo and ex vivo, mediated by the inositol-3-phosphate receptor, the calcium pump SERCA and gap junction component Inx2.