Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes

Abstract

Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.

Keywords

• amadori-glycated phosphatidylethanolamine
• curcumin
• glucose transporter
• glycolipid
• liposome
• maillard reaction product