Evolution of the fish heart by sub/neofunctionalization of an elastin gene

Yuuta Moriyama; Fumihiro Ito; Hiroyuki Takeda; Tohru Yano; Masataka Okabe; Shigehiro Kuraku; Fred W. Keeley; Kazuko Koshiba-Takeuchi

doi:10.1038/ncomms10397

Nature Communications (Jan 2016)

Evolution of the fish heart by sub/neofunctionalization of an elastin gene

Yuuta Moriyama,
Fumihiro Ito,
Hiroyuki Takeda,
Tohru Yano,
Masataka Okabe,
Shigehiro Kuraku,
Fred W. Keeley,
Kazuko Koshiba-Takeuchi

Affiliations

Yuuta Moriyama: Division of Cardiovascular Regeneration, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Fumihiro Ito: Division of Ecological Genetics, National Institute of Genetics
Hiroyuki Takeda: Department of Biological Sciences, Graduate School of Science, The University of Tokyo
Tohru Yano: Department of Anatomy, The Jikei University School of Medicine
Masataka Okabe: Department of Anatomy, The Jikei University School of Medicine
Shigehiro Kuraku: Phyloinformatics Unit, RIKEN Center for Life Science Technologies
Fred W. Keeley: Research Institute, The Hospital for Sick Children
Kazuko Koshiba-Takeuchi: Division of Cardiovascular Regeneration, Institute of Molecular and Cellular Biosciences, The University of Tokyo

DOI: https://doi.org/10.1038/ncomms10397
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The bulbus arteriosus is an organ unique to the heart of teleosts, composed of specialized smooth muscle. Here, the authors show that the gene elastin b, which regulates cell fate of cardiac precursor cells into smooth muscle, evolved after whole-genome duplication and neofunctionalization in teleosts.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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