Nature Communications (Aug 2021)
Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma
- Kylee H. Maclachlan,
- Even H. Rustad,
- Andriy Derkach,
- Binbin Zheng-Lin,
- Venkata Yellapantula,
- Benjamin Diamond,
- Malin Hultcrantz,
- Bachisio Ziccheddu,
- Eileen M. Boyle,
- Patrick Blaney,
- Niccolò Bolli,
- Yanming Zhang,
- Ahmet Dogan,
- Alexander M. Lesokhin,
- Gareth J. Morgan,
- Ola Landgren,
- Francesco Maura
Affiliations
- Kylee H. Maclachlan
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Even H. Rustad
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Andriy Derkach
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Binbin Zheng-Lin
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Venkata Yellapantula
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Benjamin Diamond
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Malin Hultcrantz
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Bachisio Ziccheddu
- Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami
- Eileen M. Boyle
- Myeloma Research Program, NYU Langone, Perlmutter Cancer Center
- Patrick Blaney
- Myeloma Research Program, NYU Langone, Perlmutter Cancer Center
- Niccolò Bolli
- Department of Oncology and Hemato-Oncology, University of Milan
- Yanming Zhang
- Cytogenetics Laboratory, Department of Pathology, Memorial Sloan Kettering Cancer Center
- Ahmet Dogan
- Hematopathology Service, Department of Pathology, Memorial Sloan Kettering Cancer Center
- Alexander M. Lesokhin
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Gareth J. Morgan
- Myeloma Research Program, NYU Langone, Perlmutter Cancer Center
- Ola Landgren
- Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami
- Francesco Maura
- Myeloma Service, Sylvester Comprehensive Cancer Center, University of Miami
- DOI
- https://doi.org/10.1038/s41467-021-25469-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Chromothripsis is associated with unfavourable outcomes in multiple myeloma (MM), but its detection usually requires whole genome sequencing. Here the authors develop an approach to detect chromothripsis in MM based on copy-number signatures that also works with whole exome sequencing data.
