Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity

Cheng Zong; Ranjith Premasiri; Haonan Lin; Yimin Huang; Chi Zhang; Chen Yang; Bin Ren; Lawrence D. Ziegler; Ji-Xin Cheng

doi:10.1038/s41467-019-13230-1

Nature Communications (Nov 2019)

Plasmon-enhanced stimulated Raman scattering microscopy with single-molecule detection sensitivity

Cheng Zong,
Ranjith Premasiri,
Haonan Lin,
Yimin Huang,
Chi Zhang,
Chen Yang,
Bin Ren,
Lawrence D. Ziegler,
Ji-Xin Cheng

Affiliations

Cheng Zong: Department of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University
Ranjith Premasiri: Department of Chemistry, Boston University
Haonan Lin: Department of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University
Yimin Huang: Department of Chemistry, Boston University
Chi Zhang: Department of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University
Chen Yang: Department of Chemistry, Boston University
Bin Ren: State Key Laboratory of Physical Chemistry of Solid Surfaces, MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University
Lawrence D. Ziegler: Department of Chemistry, Boston University
Ji-Xin Cheng: Department of Electrical and Computer Engineering, Department of Biomedical Engineering, Boston University

DOI: https://doi.org/10.1038/s41467-019-13230-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Stimulated Raman scattering (SRS) microscopy enables label-free chemical imaging at high speed, but has been limited by low sensitivity. Here, the authors demonstrate plasmon-enhanced SRS microscopy and achieve single molecule detection sensitivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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