Modeling and simulation of the morphology evolution of immiscible polymer blends during injection molding is crucial for predicting and tailoring the products’ performance. This paper reviews the state-of-the-art progress in the multiscale modeling and simulation of injection molding of polymer blends. Technological development of the injection molding simulation on a macroscale was surveyed in detail. The aspects of various models for morphology evolution on a mesoscale during injection molding were discussed. The current scale-bridging strategies between macroscopic mold-filling flow and mesoscopic morphology evolution, as well as the pros and cons of the solutions, were analyzed and compared. Finally, a comprehensive summary of the above models is presented, along with the outlook for future research in this field.