Wellcome Open Research (Jul 2021)
Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments [version 2; peer review: 2 approved]
- Tina Habota,
- Anca-Larisa Sandu,
- Gordon D. Waiter,
- Christopher J. McNeil,
- J. Douglas Steele,
- Jennifer A. Macfarlane,
- Heather C. Whalley,
- Ruth Valentine,
- Dawn Younie,
- Nichola Crouch,
- Emma L. Hawkins,
- Yoriko Hirose,
- Liana Romaniuk,
- Keith Milburn,
- Gordon Buchan,
- Tessa Coupar,
- Mairi Stirling,
- Baljit Jagpal,
- Beverly MacLennan,
- Lucasz Priba,
- Mathew A. Harris,
- Jonathan D. Hafferty,
- Mark J. Adams,
- Archie I. Campbell,
- Donald J. MacIntyre,
- Alison Pattie,
- Lee Murphy,
- Rebecca M. Reynolds,
- Rebecca Elliot,
- Ian S. Penton-Voak,
- Marcus R. Munafò,
- Kathryn L. Evans,
- Jonathan R. Seckl,
- Joanna M. Wardlaw,
- Stephen M. Lawrie,
- Christopher S. Haley,
- David J. Porteous,
- Ian J. Deary,
- Alison D. Murray,
- Andrew M. McIntosh
Affiliations
- Tina Habota
- University of Aberdeen, Aberdeen, UK
- Anca-Larisa Sandu
- University of Aberdeen, Aberdeen, UK
- Gordon D. Waiter
- University of Aberdeen, Aberdeen, UK
- Christopher J. McNeil
- University of Aberdeen, Aberdeen, UK
- J. Douglas Steele
- University of Dundee, Dundee, UK
- Jennifer A. Macfarlane
- Ninewells Hospital & Medical School, Dundee, UK
- Heather C. Whalley
- University of Edinburgh, Edinburgh, UK
- Ruth Valentine
- University of Aberdeen, Aberdeen, UK
- Dawn Younie
- University of Aberdeen, Aberdeen, UK
- Nichola Crouch
- University of Aberdeen, Aberdeen, UK
- Emma L. Hawkins
- University of Edinburgh, Edinburgh, UK
- Yoriko Hirose
- University of Edinburgh, Edinburgh, UK
- Liana Romaniuk
- University of Edinburgh, Edinburgh, UK
- Keith Milburn
- University of Dundee, Dundee, UK
- Gordon Buchan
- University of Aberdeen, Aberdeen, UK
- Tessa Coupar
- University of Dundee, Dundee, UK
- Mairi Stirling
- University of Dundee, Dundee, UK
- Baljit Jagpal
- University of Dundee, Dundee, UK
- Beverly MacLennan
- University of Aberdeen, Aberdeen, UK
- Lucasz Priba
- University of Dundee, Dundee, UK
- Mathew A. Harris
- University of Edinburgh, Edinburgh, UK
- Jonathan D. Hafferty
- University of Edinburgh, Edinburgh, UK
- Mark J. Adams
- University of Edinburgh, Edinburgh, UK
- Archie I. Campbell
- University of Edinburgh, Edinburgh, UK
- Donald J. MacIntyre
- University of Edinburgh, Edinburgh, UK
- Alison Pattie
- University of Edinburgh, Edinburgh, UK
- Lee Murphy
- University of Edinburgh, Edinburgh, UK
- Rebecca M. Reynolds
- Queen’s Medical Research Institute, Edinburgh, UK
- Rebecca Elliot
- University of Manchester, Manchester, UK
- Ian S. Penton-Voak
- University of Bristol, Bristol, UK
- Marcus R. Munafò
- University of Bristol, Bristol, UK
- Kathryn L. Evans
- University of Edinburgh, Edinburgh, UK
- Jonathan R. Seckl
- University of Edinburgh, Edinburgh, UK
- Joanna M. Wardlaw
- University of Edinburgh, Edinburgh, UK
- Stephen M. Lawrie
- University of Edinburgh, Edinburgh, UK
- Christopher S. Haley
- University of Edinburgh, Edinburgh, UK
- David J. Porteous
- University of Edinburgh, Edinburgh, UK
- Ian J. Deary
- University of Edinburgh, Edinburgh, UK
- Alison D. Murray
- University of Aberdeen, Aberdeen, UK
- Andrew M. McIntosh
- University of Edinburgh, Edinburgh, UK
- DOI
- https://doi.org/10.12688/wellcomeopenres.15538.2
- Journal volume & issue
-
Vol. 4
Abstract
STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures relevant to the study of depression, psychological resilience, and cognition. In addition, routinely collected historic NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.
