Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope

Abstract

CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and proper synapsis of homologous chromosomes.