NeuroImage: Clinical (Jan 2025)
Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study
- Jun Kanzawa,
- Ryo Kurokawa,
- Tsunehiko Takamura,
- Nobuhiro Nohara,
- Kouhei Kamiya,
- Yoshiya Moriguchi,
- Yasuhiro Sato,
- Yumi Hamamoto,
- Tomotaka Shoji,
- Tomohiko Muratsubaki,
- Motoaki Sugiura,
- Shin Fukudo,
- Yoshiyuki Hirano,
- Yusuke Sudo,
- Rio Kamashita,
- Sayo Hamatani,
- Noriko Numata,
- Koji Matsumoto,
- Eiji Shimizu,
- Naoki Kodama,
- Shingo Kakeda,
- Masatoshi Takahashi,
- Satoru Ide,
- Kazumasa Okada,
- Shu Takakura,
- Motoharu Gondo,
- Kazufumi Yoshihara,
- Masanori Isobe,
- Keima Tose,
- Tomomi Noda,
- Ryo Mishima,
- Michiko Kawabata,
- Shun’ichi Noma,
- Toshiya Murai,
- Kazuhiro Yoshiuchi,
- Atsushi Sekiguchi,
- Osamu Abe
Affiliations
- Jun Kanzawa
- Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- Ryo Kurokawa
- Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Corresponding author.
- Tsunehiko Takamura
- Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
- Nobuhiro Nohara
- Department of Psychosomatic Medicine, The University of Tokyo Hospital, Tokyo, Japan
- Kouhei Kamiya
- Department of Radiology, Toho University Omori Faculty of Medicine, Tokyo, Japan
- Yoshiya Moriguchi
- Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
- Yasuhiro Sato
- Department of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan; Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
- Yumi Hamamoto
- Creative Interdisciplinary Research Division, The Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan; Research Institute of Electrical Communication, Tohoku University, Sendai, Japan
- Tomotaka Shoji
- Nagamachi Hospital, Sendai, Japan
- Tomohiko Muratsubaki
- Department of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan
- Motoaki Sugiura
- Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; International Research Institute of Disaster Science, Tohoku University, Sendai, Japan
- Shin Fukudo
- Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, Japan
- Yoshiyuki Hirano
- Research Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Applied MRI Research, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan
- Yusuke Sudo
- Research Center for Child Mental Development Chiba University, Chiba, Japan; Department of Cognitive Behavioral Physiology, Chiba University, Chiba, Japan; Department of Psychiatry, Chiba University Hospital, Chiba, Japan
- Rio Kamashita
- Research Center for Child Mental Development Chiba University, Chiba, Japan; Department of Rehabilitation, Faculty of Health Sciences, Hiroshima Cosmopolitan University, Hiroshima, Japan
- Sayo Hamatani
- Research Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Research Center for Child Mental Development Fukui University, Eiheizi, Japan
- Noriko Numata
- Research Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Department of Cognitive Behavioral Physiology, Chiba University, Chiba, Japan
- Koji Matsumoto
- Department of Radiology, Chiba University Hospital, Chiba, Japan
- Eiji Shimizu
- Research Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Department of Cognitive Behavioral Physiology, Chiba University, Chiba, Japan
- Naoki Kodama
- Division of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, Japan
- Shingo Kakeda
- Department of Radiology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan
- Masatoshi Takahashi
- Division of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, Japan
- Satoru Ide
- Department of Radiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
- Kazumasa Okada
- Department of Neurology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan
- Shu Takakura
- Department of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, Japan
- Motoharu Gondo
- Department of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, Japan
- Kazufumi Yoshihara
- Department of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, Japan
- Masanori Isobe
- Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Keima Tose
- Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Tomomi Noda
- Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Ryo Mishima
- Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Michiko Kawabata
- Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Shun’ichi Noma
- Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Nomakokoro Clinic, Kyoto, Japan
- Toshiya Murai
- Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan
- Kazuhiro Yoshiuchi
- Department of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- Atsushi Sekiguchi
- Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Center for Eating Disorder Research and Information, National Center of Neurology and Psychiatry, Tokyo, Japan
- Osamu Abe
- Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- DOI
- https://doi.org/10.1016/j.nicl.2025.103737
- Journal volume & issue
-
Vol. 45
p. 103737
Abstract
Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.
Keywords
- Anorexia Nervosa (AN)
- Diffusion MRI
- Structural Connectivity
- Graph Theory
- Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD)
