Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment

Yang Mei; Xu Han; Yijie Liu; Jing Yang; Ronen Sumagin; Peng Ji

doi:10.1038/s41467-020-16911-4

Nature Communications (Jun 2020)

Diaphanous-related formin mDia2 regulates beta2 integrins to control hematopoietic stem and progenitor cell engraftment

Yang Mei,
Xu Han,
Yijie Liu,
Jing Yang,
Ronen Sumagin,
Peng Ji

Affiliations

Yang Mei: Department of Pathology, Feinberg School of Medicine, Northwestern University
Xu Han: Department of Pathology, Feinberg School of Medicine, Northwestern University
Yijie Liu: Department of Pathology, Feinberg School of Medicine, Northwestern University
Jing Yang: Department of Pathology, Feinberg School of Medicine, Northwestern University
Ronen Sumagin: Department of Pathology, Feinberg School of Medicine, Northwestern University
Peng Ji: Department of Pathology, Feinberg School of Medicine, Northwestern University

DOI: https://doi.org/10.1038/s41467-020-16911-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Bone marrow engraftment of haematopoietic stem and progenitor cells (HSPCs) requires homing and lodgement to the niche. Here, the authors show that mDia2 is required for HSPC polarization, nuclear MAL, and SRF-induced beta2 integrin expression during transendothelial migration of HSPCs required for engraftment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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