Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells

Minchenko Dmytro O.; Khita Olena O.; Viletska Yuliia M.; Sliusar Myroslava Y.; Rudnytska Olha V.; Kozynkevych Halyna E.; Bezrodnyi Borys H.; Khikhlo Yevgen P.; Minchenko Oleksandr H.

doi:10.2478/enr-2024-0001

Endocrine Regulations (Jan 2024)

Cortisol controls endoplasmic reticulum stress and hypoxia dependent regulation of insulin receptor and related genes expression in HEK293 cells

Minchenko Dmytro O.,
Khita Olena O.,
Viletska Yuliia M.,
Sliusar Myroslava Y.,
Rudnytska Olha V.,
Kozynkevych Halyna E.,
Bezrodnyi Borys H.,
Khikhlo Yevgen P.,
Minchenko Oleksandr H.

Affiliations

Minchenko Dmytro O.: 1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, Ukraine
Khita Olena O.: 1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, Ukraine
Viletska Yuliia M.: 1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, Ukraine
Sliusar Myroslava Y.: 1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, Ukraine
Rudnytska Olha V.: 1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, Ukraine
Kozynkevych Halyna E.: 2Departments of Pediatrics No.1 and Surgery, National Bohomolets Medical University, Kyiv, Ukraine
Bezrodnyi Borys H.: 2Departments of Pediatrics No.1 and Surgery, National Bohomolets Medical University, Kyiv, Ukraine
Khikhlo Yevgen P.: 1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, Ukraine
Minchenko Oleksandr H.: 1Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev01030, Ukraine

DOI: https://doi.org/10.2478/enr-2024-0001
Journal volume & issue: Vol. 58, no. 1
pp. 1 – 10

Abstract

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Objective. Glucocorticoids are important stress-responsive regulators of insulin-dependent metabolic processes realized through specific changes in genome function. The aim of this study was to investigate the impact of cortisol on insulin receptor and related genes expression in HEK293 cells upon induction the endoplasmic reticulum (ER) stress by tunicamycin and hypoxia.

Published in Endocrine Regulations

ISSN: 1336-0329 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://sciendo.com/journal/ENR

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