Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Sungjun Park; Seungwon Lee; Choong-Gu Lee; Guk Yeol Park; Hyebeen Hong; Jeon-Soo Lee; Young Min Kim; Sung Bae Lee; Daehee Hwang; Youn Soo Choi; John D. Fryer; Sin-Hyeog Im; Seung-Woo Lee; Yoontae Lee

doi:10.1038/ncomms16037

Nature Communications (Jul 2017)

Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Sungjun Park,
Seungwon Lee,
Choong-Gu Lee,
Guk Yeol Park,
Hyebeen Hong,
Jeon-Soo Lee,
Young Min Kim,
Sung Bae Lee,
Daehee Hwang,
Youn Soo Choi,
John D. Fryer,
Sin-Hyeog Im,
Seung-Woo Lee,
Yoontae Lee

Affiliations

Sungjun Park: Department of Life Sciences, Pohang University of Science and Technology
Seungwon Lee: Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology
Choong-Gu Lee: Academy of Immunology and Microbiology, Institute for Basic Science
Guk Yeol Park: Department of Life Sciences, Pohang University of Science and Technology
Hyebeen Hong: Department of Life Sciences, Pohang University of Science and Technology
Jeon-Soo Lee: Department of Life Sciences, Pohang University of Science and Technology
Young Min Kim: Department of Life Sciences, Pohang University of Science and Technology
Sung Bae Lee: Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST)
Daehee Hwang: Center for Plant Aging Research, Institute for Basic Science, DGIST
Youn Soo Choi: Department of Biomedical Sciences, Department of Medicine, Seoul National University College of Medicine
John D. Fryer: Department of Neuroscience, Mayo Clinic
Sin-Hyeog Im: Department of Life Sciences, Pohang University of Science and Technology
Seung-Woo Lee: Department of Life Sciences, Pohang University of Science and Technology
Yoontae Lee: Department of Life Sciences, Pohang University of Science and Technology

DOI: https://doi.org/10.1038/ncomms16037
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH differentiation and GC responses potentially via the derepression of Etv5.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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